Observational studyThe journal of nutrition, health & aging2025
Poor clinical outcomes associated to multimorbidity, frailty and malnutrition in patients with atrial fibrillation.
Observational study in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Phenotypic determinants of atrial fibrillation in ischaemic stroke: a retrospective study.Open heart · 2026Article
- Navigating Anticoagulation Decisions in Atrial Fibrillation and Frailty Comorbidity.Life (Basel, Switzerland) · 2026Review
- Nutritional Indices Are Associated with Mortality in the Elderly Patients Undergoing Left Atrial Appendage Occlusion: A Comparative Study of CONUT, GNRI, and PNI.Journal of cardiovascular development and disease · 2026Article
- Impact of seasonal temperature variations on adverse outcomes in atrial fibrillation: comparative insights from Vigo and Murcia cohorts.Journal of global health · 2026Article
- Prediction model for frailty risk in ischemic stroke patients: Application and validation of support vector machines and nomograms.Medicine · 2026Article
- The role of comorbidity and frailty in shaping the burden of atrial fibrillation: a multinational cross-sectional survey.Scientific reports · 2026Article
- Association of Prognostic Nutritional Index and New-Onset Atrial Fibrillation in Patients Undergoing Surgical Aortic Valve Replacement: A Silent Predictor in Perioperative Outcomes?Journal of clinical medicine · 2026Article
- Uric acid-to-albumin ratio as a cardiometabolic marker for predicting adverse outcomes in patients with atrial fibrillation: evidence from two independent cohorts.Frontiers in endocrinology · 2026Article
- Anticoagulation in Frail Older Adults with Non-Valvular Atrial Fibrillation: Clinical Challenges and Personalized Approach.Journal of clinical medicine · 2025Review
- Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) patients often present with a higher prevalence of comorbidities, frailty, and malnutrition. We investigated if multimorbidity, frailty and malnutrition were associated with clinical outcomes in patients with AF starting vitamin K antagonist (VKA) therapy.
methodsProspective observational cohort study including AF outpatients starting VKAs from July 2016 to June 2018. Multimorbidity was assessed by the number of comorbidities, frailty was evaluated using the Clinical Frailty Scale (CFS), and nutritional status was appraised using the Controlling Nutritional Status (CONUT). During 2-years of follow-up, ischemic strokes/transient ischemic attacks (TIA), major bleeds, and all-cause deaths, were recorded.
results1050 AF patients (51.4% female; median age 77 years, IQR 70-83) were included. Of these, 912 (86.9%) had multimorbidity (≥2 comorbidities additional to AF), 186 (17.7%) exhibited any frailty degree (CFS ≥ 5), and 76 (7.2%) had moderate-to-severe malnutrition (CONUT ≥ 5). The crude number of comorbidities and the CFS were significantly associated with major bleeds, whereas the CFS and the CONUT score were related to all-cause mortality. After adjustment, any frailty degree was associated with higher risks of major bleeding (aHR 3.04, 95% CI 1.67-5.52) and death (aHR 2.04, 95% CI 1.39-3.01). Moderate-to-severe malnutrition increased risk for ischemic stroke/TIA (aHR 2.25, 95% CI 1.11-4.56) and all-cause mortality (aHR 3.21, 95% CI 2.14-4.83).
conclusionsIn this real-world prospective cohort of AF taking VKAs, most patients had multiple comorbidities, frailty and malnutrition. Frailty and malnutrition were important risk factors for bleeding, stroke, and mortality in these patients.
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