Evidence map›Paper›PMID 39615574›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2025

Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.

Rachel L Miller, Yuyan Wang, Jenny Aalborg, Akram N Alshawabkeh, Deborah H Bennett, Carrie V Breton, Jessie P Buckley, Dana Dabelea, Anne L Dunlop, Assiamira Ferrara and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. The association between environmental endocrine-disrupting chemicals and allergic disorders in children: A comprehensive systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Rachel L MillerIcahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. Electronic address: rachel.miller2@mssm.edu.
Yuyan WangNYU Grossman School of Medicine, 180 Madison Ave, New York, NY, USA. Electronic address: Yuyan.Wang@nyulangone.org.
Jenny AalborgUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Jenny.Aalborg@cuanschutz.edu.
Akram N AlshawabkehNortheastern University, Department of Civil and Environmental Engineering, Boston, MA, USA. Electronic address: a.alshawabkeh@northeastern.edu.
Deborah H BennettDepartment of Public Health Science, University of California, Davis, CA, USA. Electronic address: dhbennett@ucdavis.edu.
Carrie V BretonDepartment of Population and Public Health Sciences, University of Southern, CA, USA. Electronic address: breton@usc.edu.
Jessie P BuckleyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2106-B McGavran-Greenberg Hall CB#7435, Chapel Hill, NC, USA. Electronic address: 27599-7435Jessie.Buckley@unc.edu.
Dana DabeleaUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Coloradodana.dabelea@cuanschutz.edu.
Anne L DunlopDepartment of Gynecology & Obstetrics, Emory University School of Medicine, 101 Woodruff Circle, Rm 4313, Woodruff Memorial Building, Atlanta, GA, 30322, USA. Electronic address: amlang@emory.edu.
Assiamira FerraraDivision of Research Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA. Electronic address: Assiamira.Ferrara@kp.org.
Griffith GaoNortheastern University, Department of Civil and Environmental Engineering, Boston, MA, USA. Electronic address: q.gao@northeastern.edu.
Abigail GaylordDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. Electronic address: alg2215@cumc.columbia.edu.
Diane R GoldGold the Department of Environmental Health, Harvard T.H. Chan School of Public Health, and the Channing Division of Network Medicine, Harvard Medical School, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States Boston, MA, USA. Electronic address: dgold@hsph.harvard.edu.
Tina HartertVanderbilt University Medical Center, Nashville, TN, USA. Electronic address: tina.hartert@vumc.org.
Irva Hertz-PicciottoDepartment of Public Health Science, University of California, Davis, CA, USA. Electronic address: iher@ucdavis.edu.
Lori A HoepnerSUNY Downstate Health Sciences University, Department of Environmental and Occupational Health Sciences, Brooklyn, NY, 11230, USA. Electronic address: Lori.Hoepner@downstate.edu.
Margaret KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: margaret.r.karagas@dartmouth.edu.
Catherine J KarrUniversity of Washington, Departments of Pediatrics, Environmental & Occupational Health Sciences, Seattle, 4225 Roosevelt Way NE, Suite 100, WA, 98105, USA. Electronic address: ckarr@uw.edu.
Rachel S KellyChanning Division of Network Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: hprke@channing.harvard.edu.
Camilo KhatchikianDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Electronic address: Camilo.Khatchikian@dartmouth.edu.
Mengling LiuNYU Grossman School of Medicine, 180 Madison Ave, New York, NY, USA. Electronic address: Mengling.Liu@nyulangone.org.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.
Thomas G O'ConnorDepartments of Psychiatry, Neuroscience, Obstetrics and Gynecology, University of Rochester, 300 Crittenden Blvd, Rochester, NY, 14642, USA. Electronic address: tom_oconnor@urmc.rochester.edu.
Alicia K PetersonDivision of Research Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA. Electronic address: Alicia.K.Peterson@kp.org.
Sheela SathyanarayanaDepartment of Pediatrics, Department of Environmental and Occupational Health Sciences, Department of Epidemiology, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, University of Washington, Seattle, WA, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.org.
Joanne SordilloDepartment of Population Medicine, Harvard Pilgrim Healthcare Institute, Harvard Medical School, Boston, MA, USA. Electronic address: joanne.e.sordillo@gmail.com.
Leonardo TrasandeDepartments of Pediatrics and Population Health, NYU Grossman School of Medicine, New York, NY, USA. Electronic address: Leonardo.Trasande@nyulangone.org.
Scott T WeissChanning Division of Network Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: restw@channing.harvard.edu.
Yeyi ZhuDivision of Research Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA. Electronic address: yeyi.zhu@kp.org.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and ProcessingU24OD035523 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Suman Ranjan Das, NATASHA Bassam HALASA · 2023 to 2026
$32.8M
Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K01 HL146980NICHD NIH HHS UG1 HD104252NIDDK NIH HHS R01 DK076648NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES001247NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P42 ES017198NIEHS NIH HHS R01 ES016863NIEHS NIH HHS R01 ES022934NIEHS NIH HHS R01 ES032808NIEHS NIH HHS T32 ES007322NIEHS NIH HHS U24 ES026539NIEHS NIH HHS U2C ES026533NIEHS NIH HHS U2C ES026542NIEHS NIH HHS U2C ES026555NIEHS NIH HHS U2C ES026561NIEHS NIH HHS U2C ES030851NIEHS NIH HHS U2C ES030857NIEHS NIH HHS U2C ES030859NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U24 OD035523NIH HHS U2C OD023375NIH HHS UG3 OD023244NIH HHS UG3 OD023249NIH HHS UG3 OD023251NIH HHS UG3 OD023253NIH HHS UG3 OD023271NIH HHS UG3 OD023272NIH HHS UG3 OD023275NIH HHS UG3 OD023279NIH HHS UG3 OD023285NIH HHS UG3 OD023289NIH HHS UG3 OD023290NIH HHS UG3 OD023305NIH HHS UG3 OD023313NIH HHS UG3 OD023318NIH HHS UG3 OD023328NIH HHS UG3 OD023337NIH HHS UG3 OD023342NIH HHS UG3 OD023344NIH HHS UG3 OD023347NIH HHS UG3 OD023348NIH HHS UG3 OD023349NIH HHS UG3 OD023365NIH HHS UG3 OD035508NIH HHS UG3 OD035509NIH HHS UG3 OD035513NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035519NIH HHS UG3 OD035521NIH HHS UG3 OD035526NIH HHS UG3 OD035527NIH HHS UG3 OD035528NIH HHS UG3 OD035529NIH HHS UG3 OD035532NIH HHS UG3 OD035533NIH HHS UG3 OD035536NIH HHS UG3 OD035537NIH HHS UG3 OD035540NIH HHS UG3 OD035542NIH HHS UG3 OD035543NIH HHS UG3 OD035544NIH HHS UG3 OD035546NIH HHS UG3 OD035550NIH HHS UH3 OD023244NIH HHS UH3 OD023251NIH HHS UH3 OD023253NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023279NIH HHS UH3 OD023286NIH HHS UH3 OD023287NIH HHS UH3 OD023290NIH HHS UH3 OD023313NIH HHS UH3 OD023318NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023332NIH HHS UH3 OD023347NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIH HHS UH3 OD023389NIH HHS UH3 OD035509NIH HHS UH3 OD035516NIH HHS UH3 OD035518NIH HHS UH3 OD035521NIH HHS UH3 OD035529NIH HHS UH3 OD035542NIH HHS UH3 OD035543
6 · The paper itself

Abstract

Concerns persist about the potential impact of prenatal exposure to bisphenols (BP) and their replacement analogues on childhood asthma and allergies. Previous studies on single and small cohorts had limited statistical power, few investigated analogues BPF and BPS, and even fewer examined atopic outcomes. Our objective was to assess whether prenatal exposures to individual environmental bisphenols (BPA, BPF, BPS) influence risk of childhood asthma, allergic rhinitis, and atopic dermatitis. Data from the U.S. Environmental Influences on Child Health Outcomes (ECHO) consortium were harmonized on measures of prenatal urinary BPA, BPF and BPS and asthma and allergic rhinitis (ages 5-9 years) and atopic dermatitis (up to age 3 years) from 1905 mother-child pairs that were collected between 1998 and 2017. Across the 2012 federal ban of BPA from certain infant products, median BPA levels decreased from 1.11 ng/ml to 0.86 ng/ml; median BPF levels decreased from 0.51 ng/ml to 0.39 ng/ml; and median BPS levels increased from 0.23 ng/ml to 0.31 ng/ml (dilution adjusted; p < 0.001 for all three median comparisons). Prenatal measures of BPA, BPF, and BPS were unrelated to the risk of childhood asthma, allergic rhinitis, or atopic dermatitis in the total population. Modest sex-dependent effects were observed: only among girls, second tertile levels of BPF was associated with a reduced odds of asthma (odds ratio (OR) 0.27, 95% confidence interval (CI) 0.08, 0.93); a continuous index of prenatal BPS was associated with reduced odds of atopic dermatitis (OR 0.64, 95% CI 0.44, 0.93). The ongoing and changing patterns of exposure to bisphenols in the U.S. population require further study with additional attention to time windows of exposure and co-occurring social determinants of health, to continue to inform current policies and evaluate the importance of limiting exposure to BPA and its analogues on childhood asthma, allergic rhinitis, and atopic dermatitis.

Indexed as

AsthmaBenzhydryl CompoundsDermatitis, AtopicEnvironmental ExposureEnvironmental PollutantsMaternal ExposurePhenolsPrenatal Exposure Delayed EffectsRhinitis, AllergicAdultBisphenol A CompoundsBisphenolsChildChild, PreschoolFemaleHumansBenzhydryl Compoundsbisphenol ABisphenol A CompoundsBisphenolsEnvironmental PollutantsPhenolsBisphenolsChildhood allergyChildhood asthmaEnvironmental influences on child health outcomesPrenatal chemical exposure

Identifiers

PMID39615574
PMCPMC12120670

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.