Evidence map›Paper›PMID 39615753›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2025

Photothrombolytics: A light-driven technology for the targeted lysis of thrombi.

Basanta Acharya, Caylie A McGlade, Haifeng Yin, Tomohiro Kawano, Lauren Haar, Nigel Mackman, Rani S Sellers, Xianming Tan, Aadra P Bhatt, David S Lawrence and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Basanta AcharyaDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Caylie A McGladeDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Haifeng YinMcAllister Heart Institute, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Tomohiro KawanoDivision of Hematology, Department of Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Lauren HaarDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Nigel MackmanDivision of Hematology, Department of Medicine, UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Rani S SellersDepartment of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Xianming TanDepartment of Biostatistics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Aadra P BhattDivision of Gastroenterology & Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
David S LawrenceDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Brianna M VickermanEshelman Innovation, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address: brianna.vickerman@unc.edu.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Design and Application of Photoresponsive Modules in Circulating ErythrocytesR01HL153744 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAWRENCE, DAVID S. · 2021 to 2024
$2.7M
UNC Chemical Biology Interface Training ProgramT32GM135122 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jeffrey Aube · 2021 to 2026
$1.6M
NCI NIH HHS P30 CA016086NHLBI NIH HHS R01 HL153744NIGMS NIH HHS T32 GM135122
6 · The paper itself

Abstract

Occlusive blood clots remain a significant global health challenge and result in emergencies that are main causes of death and disability worldwide. Thrombolytic agents (including tissue plasminogen activator, tPA) are the only pharmacological means to dissolve blood clots. However, these drugs have modest efficacy and severe safety concerns persist. We have developed light-responsive tPA-loaded red blood cells (tPA-RBCs

Indexed as

Fibrinolytic AgentsThrombolytic TherapyThrombosisTissue Plasminogen ActivatorAnimalsErythrocytesHumansLightMiceMice, Inbred C57BLFibrinolytic AgentsTissue Plasminogen ActivatorBiological carriersDrug deliveryPhototherapeuticsThrombolytics

Identifiers

PMID39615753
PMCPMC11830540

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.