Evidence map›Paper›PMID 39616189›Full record

ArticleScientific reports2024

A multicenter trial on the predictors of different subtypes of hemorrhagic infarction after thrombolysis.

Mohamed G Zeinhom, Sherihan Rezk Ahmed, Ahmed Mohamed Kohail, Islam Fathallah Mohamed Kamel, ALshimaa Mahfouz Abdelrahman, Omar M Al-Nozha, Mohamed Almoataz, Tarek Youssif Omar Youssif, Ahmed Mohamed Ali Daabis, Hossam Mohamed Refat and 7 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06337175 (Predictors of Post-alteplase Different Subtypes of Hemorrhagic Transformation of Brain Infarction in the Middle East), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06337175 phase4completednot on this map

Predictors of Post-alteplase Different Subtypes of Hemorrhagic Transformation of Brain Infarction in the Middle East

TypeinterventionalSponsorKafrelsheikh UniversityRan2021 to 2024Enrolled600ConditionsIschemic Stroke, Alteplase Adverse ReactionArmsAlteplase
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Cilostazole versus clopidogrel in acute large-vessel moderate and moderate-to-severe ischemic stroke: a randomized controlled trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Trial
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mohamed G ZeinhomNeurology Department, faculty of medicine, Kafr El-sheikh university, Elgeish street, Kafr el-sheikh, Egypt. mohamed_gomaa@med.kfs.edu.eg.
Sherihan Rezk AhmedNeurology Department, faculty of medicine, Kafr El-sheikh university, Elgeish street, Kafr el-sheikh, Egypt. sherihan_rezq@med.kfs.edu.eg.
Ahmed Mohamed KohailNeurology Department, faculty of medicine, Al-Azhar university, ELmokhaim St., Cairo, Egypt.
Islam Fathallah Mohamed KamelNeurology Department, faculty of medicine, Tanta university, ELbahr St., Tanta, Egypt.
ALshimaa Mahfouz AbdelrahmanRadiology Department, faculty of medicine, ELminia university, ELgomhoria St., Minya, Egypt.
Omar M Al-NozhaMedicine Department, College of Medicine, Taibah University, 23 ELhars st., Madina, Saudi Arabia.
Mohamed AlmoatazNeurology Department, Saudi German hospital, Sharjah, United Arab Emirates.
Tarek Youssif Omar YoussifNeurology Department, Burjeel medical city Abu Dhabi, Abu Dhabi, United Arab Emirates.
Ahmed Mohamed Ali DaabisNeurology Department, Burjeel Royal Hospital Al Ain, Al Ain, United Arab Emirates.
Hossam Mohamed RefatNeurology Department, Faculty of medicine Zagazig university, 2 elgeish Et, Zagazig, Egypt.
Ahmed Ahmed Mohamed Kamal EbiedNeurology Department, Faculty of medicine Zagazig university, 2 elgeish Et, Zagazig, Egypt.
Ahmed ElbassiounyNeurology department, faculty of medicine, Ain shams university, ELabbasia St., Al khalifa elmamon St., Cairo, Egypt.
Ahmed Zaki Omar AklNeurology department, faculty of medicine, Ain shams university, ELabbasia St., Al khalifa elmamon St., Cairo, Egypt.
Ashfaq ShuaibDivision of neurology, department of medicine, University of Alberta, Clinical sciences building, Edmonton, AB, T6G 2R3, Canada.
Mohamed IsmaielNeurology Department, El-Sahel Teaching hospital, 2 Yossef Karam, El Sahel, Cairo, 11697, Egypt.
Asmaa Ibrahem Desouky Mostafa IbrahemNeurology Department Al-Raml Hospital, Alexandria, Egypt.
Mohamed Fouad Elsayed KhalilNeurology Department, Saudi German hospital Madinah, 23 ELhars St., Madina, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. Most studies evaluated the post-alteplase haemorrhagic transformation of brain infarction as a homogeneous entity but we evaluated the predictors of each subtype of haemorrhagic transformation of brain infarction. Our trial included 616 AIS alteplase-treated patients. We evaluated the ability of different risk factors, clinical presentation, and imaging features to predict different haemorrhagic transformation (HT) subtypes. HT was seen in 152 patients (24.7%), higher NIHSS, cardioembolic stroke and atrial fibrillation were independent predictors of all ECASS-based subtypes of hemorrhagic infarction, in addition, anterior-circulation stroke was an independent predictor of hemorrhagic infarction type 1 (odds ratio [OR], 11.04; 95% CI, 9.81 to 12.70; P-value > 0.001) and type2 (OR, 11.89; 95% CI, 9.79 to 14.44; P-value > 0.001), while older age was also an independent predictor of parenchymal hematoma type1 (OR, 1.312; 95% CI, 1.245 to 1.912; P-value 0.02). In AIS patients treated with alteplase in Egypt and Saudi Arabia, higher NIHSS, cardioembolic stroke and atrial fibrillation were independent predictors of all ECASS-based subtypes of hemorrhagic infarction; in addition, anterior-circulation stroke was an independent predictor of hemorrhagic infarction type 1 and 2, while older age was also an independent predictor of parenchymal hematoma type1. Trial registration: (clinicaltrials.gov NCT06337175), retrospectively registered on 29/03/2024.

Indexed as

Ischemic StrokeThrombolytic TherapyTissue Plasminogen ActivatorAgedAged, 80 and overAtrial FibrillationBrain InfarctionCerebral HemorrhageFemaleFibrinolytic AgentsHumansMaleMiddle AgedRisk FactorsFibrinolytic AgentsTissue Plasminogen ActivatorAlteplaseEgyptHemorrhagic infarctionMiddle eastSaudi Arabia

Identifiers

PMID39616189
PMCPMC11608245

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.