SynthesisInternational journal of impotence research2025
Association between serum homocysteine and erectile dysfunction: a systematic review and meta-analysis.
Synthesis in International journal of impotence research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Do serum homocysteine levels affect female sexual function in reproductive-age women: a cross-sectional study.Revista da Associacao Medica Brasileira (1992) · 2026Article
- N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction.International journal of biological sciences · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this meta-analysis was to determine the relationship between erectile dysfunction (ED) and serum homocysteine (Hcy) levels. A comprehensive search was performed using databases such as Web of Science, PubMed, and the Cochrane Library to identify suitable studies published by July 2023. The statistical analysis involved calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs) using STATA software. Twelve studies with 1766 ED patients and 2340 non-ED control participants were included in this meta-analysis. The pooled results indicated that the Hcy levels of ED patients were obviously greater than those of control participants (SMD (95% CI) = 0.97 (0.51,1.43), p < 0.001). Subgroup analysis revealed a greater SMD in ED patients aged>40 years, overweight status, those with a mild-moderate International Index of Erectile function (IIEF) score, and those living in Mediterranean countries, (1.18 (0.61, 1.75), p < 0.001; 1.27 (0.72, 1.82), p < 0.001;1.63 (1.04, 2.22), p < 0.001; 1.18 (0.61, 1.75), p < 0.001, respectively). Our meta-analysis indicated that subjects with ED exhibit higher levels of serum Hcy. However, due to the existence of publication bias, more rigorous and large-sample studies are needed.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.