Evidence map›Paper›PMID 39616264›Full record

ArticleCommunications biology2024

Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity.

John J McInnis, Disha Sood, Lilu Guo, Michael R Dufault, Mariana Garcia, Rachel Passaro, Grace Gao, Bailin Zhang, James C Dodge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John J McInnis *Sanofi, Rare and Neurologic Disease, 350 Water Street, Cambridge, MA, USA. john.mcinnis@sanofi.com.ORCID 0000-0002-4805-4214
Disha Sood *Sanofi, Rare and Neurologic Disease, 350 Water Street, Cambridge, MA, USA.
Lilu GuoSanofi, Precision Medicine and Computational Biology, 350 Water Street, Cambridge, MA, USA.
Michael R DufaultSanofi, Precision Medicine and Computational Biology, 350 Water Street, Cambridge, MA, USA.ORCID 0000-0002-5124-1627
Mariana GarciaSanofi, Precision Medicine and Computational Biology, 350 Water Street, Cambridge, MA, USA.
Rachel PassaroSanofi, Rare and Neurologic Disease, 350 Water Street, Cambridge, MA, USA.ORCID 0000-0002-7895-4643
Grace GaoSanofi, Rare and Neurologic Disease, 350 Water Street, Cambridge, MA, USA.
Bailin ZhangSanofi, Precision Medicine and Computational Biology, 350 Water Street, Cambridge, MA, USA.
James C DodgeSanofi, Rare and Neurologic Disease, 350 Water Street, Cambridge, MA, USA. James.dodge@sanofi.com.ORCID 0000-0003-4466-7213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often analyzed in tissue, but this approach fails to resolve cell-type differences in ceramide homeostasis that are likely essential to understanding cell and non-cell autonomous contributions to neurodegeneration. We show that human iPSC-derived neurons and glia differ in their rate of ceramide synthesis, ceramide isoform composition, and responses to altered ceramide levels. RNA-sequencing of cells treated to increase or decrease ceramides revealed connections to inflammation, ER stress, and apoptosis. Moreover, introducing labeled sphinganine showed that glia readily synthesize ceramide de novo and that neurons are relatively more sensitive to ceramide toxicity. Our findings provide a framework for understanding neurologic diseases with sphingolipid alternations and insights into designing therapeutics that target ceramide for treating them.

Indexed as

CeramidesNeurogliaNeuronsApoptosisEndoplasmic Reticulum StressHumansInduced Pluripotent Stem CellsCeramides

Identifiers

PMID39616264
PMCPMC11608238

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.