ArticleLipids in health and disease2024
Association of triglyceride glucose index combined with obesity indicators with cognitive impairment.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity.Journal of cachexia, sarcopenia and muscle · 2026Article
- Associations of modified triglyceride-glucose indices with risks of dementia subtypes and brain structure: a prospective cohort study.Frontiers in neurology · 2026Article
- TyG index and mild cognitive impairment and dementia: a review of current evidence.Frontiers in aging neuroscience · 2026Review
- The mediating role of depressive symptoms in the relationship between obesity-related triglyceride-glucose index and cognitive status among middle-aged and elderly adults: a large cohort study.Frontiers in psychiatry · 2026Article
- Cognitive function in normotensive elderly adults: a population-based cross-sectional study in rural China.Frontiers in medicine · 2026Article
- TyG-ABSI as a novel metabolic obesity indicator for carotid plaque: an explainable machine learning study using SHAP in low-income population.BMC endocrine disorders · 2025Article
- Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.Lipids in health and disease · 2025Article
- Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort.Frontiers in physiology · 2025Article
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12 authors.
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Abstract
backgroundThe association of a combination of the TyG index and obesity markers, specifically waist circumference (WC), with cognitive function is unknown. This research investigated the relationship between TyG-WC measurements and cognitive impairment in a low-income population in China; moreover, this study evaluated the role of diabetes mellitus and body mass index (BMI) in modulating this relationship.
methods1125 eligible individuals aged ≥ 60 years participated in this study. The TyG index and obesity indicators (BMI, WC, and waist-to-height ratio) were calculated for individual participants and categorized into quartiles. Multivariate logistic regression analysis was used to evaluate the correlation between TyG-WC values and cognitive impairment; the possibility of a nonlinear relationship was explored using constrained cubic spline analysis. The participants were divided into different groups according to their diabetes status and BMI category for subgroup analyses. Linear regression was used to investigate the correlation between TyG-WC values and MMSE scores.
resultsThe prevalence of cognitive impairment in the study participants was 47.3%, with a significant negative association between TyG-WC values and cognitive impairment, (odds ratio [OR] = 0.999; 95% confidence interval [CI], 0.997-1.00, P = 0.009). A U-shaped correlation was observed between the TyG-WC values and cognitive impairment (P = 0.008). Subgroup analyses showed that the inverse association between TyG-WC values and cognitive impairment was stronger in non-diabetic individuals (OR = 0.998; 95% CI, 0.997-0.999; P = 0.002) and in those with a lower BMI (< 24 kg/m
conclusionThis study demonstrates a nonlinear U-shaped relationship between TyG-WC values and cognitive function. The stronger inverse association between TyG-WC values and cognitive decline in the non-diabetic and low-BMI subgroups suggests that these populations may benefit the most from targeted interventions. These findings are important for clinical practice and formulating disease-prevention policies, emphasizing the need for metabolic health management to prevent cognitive decline, particularly in low-income populations.
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