Evidence mapPaperPMID 39617784Full record

ReviewExperimental & molecular medicine2024

Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum.

Yongzhao Zhao, Qian Xiang, Shuo Tian, Zhenquan Wu, Jialiang Lin, Longjie Wang, Zhuoran Sun, Weishi Li

Abstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongzhao Zhao *Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
Qian Xiang *Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
Shuo Tian *Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
Zhenquan Wu *Department of Orthopaedics, Peking University Third Hospital, Beijing, China.
Jialiang LinDepartment of Orthopaedics, Peking University Third Hospital, Beijing, China.
Longjie WangDepartment of Orthopaedics, Peking University Third Hospital, Beijing, China.
Zhuoran SunDepartment of Orthopaedics, Peking University Third Hospital, Beijing, China.
Weishi LiDepartment of Orthopaedics, Peking University Third Hospital, Beijing, China. puh3liweishi@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ligamentum flavum degeneration, including hypertrophy and ossification of the ligamentum flavum, leads to degenerative spinal stenosis in older adults. However, the underlying mechanisms of ligamentum flavum degeneration remain unclear, and therapeutic strategies are limited. Noncoding RNAs include microRNAs, circular RNAs, and long noncoding RNAs. As important epigenetic modifications, noncoding RNAs are involved in the progression of several age-related diseases, including ligamentum flavum degeneration. Previous studies have shown that noncoding RNAs can regulate the osteogenic differentiation and fibrosis of ligamentum flavum cells by regulating the expression of related genes. In this review, we discuss noncoding RNAs and their role in ligamentum flavum degeneration.

Indexed as

Epigenesis, GeneticLigamentum FlavumRNA, UntranslatedAnimalsGene Expression RegulationHumansMicroRNAsRNA, CircularMicroRNAsRNA, CircularRNA, Untranslated

Identifiers

PMID39617784
PMCPMC11671540

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.