ArticleBMC immunology2024
Sex-specific relationship between serum 25-hydroxyvitamin D concentrations and antinuclear antibodies in U.S. adults, NHANES 2001-2004.
Article in BMC immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship of serum 25-hydroxyvitamin D concentrations and ANA positivity according to sex stratification is unclear. The propose of this study was to reveal the sex-specific relationship of serum 25-hydroxyvitamin D concentrations and ANA positivity in American people.
methodsThe study was conducted in 2757 subjects from the National Health and Nutrition Examination Survey (NHANES) 2001-2004. The logistic regression models were used to assess the correlation between the risk of ANA positivity and serum 25-hydroxyvitamin D concentrations. Generalized additive models and smooth fitting curves were used to evaluate the non-linear relationship of the risk of ANA positivity and serum 25-hydroxyvitamin D levels.
resultsFollowing multivariable adjustment, we observed a negative correlation between serum 25-hydroxyvitamin D concentrations and the risk of ANA positivity in male participants, particularly in men non-white individuals and those exposed to second-hand smoke. However, there was no significant relationship observed in the female participants. Additionally, the relationship between serum 25-hydroxyvitamin D concentrations and the risk of ANA positivity followed an L-shaped pattern, with an inflection point at 18 ng/mL. When serum 25-hydroxyvitamin D levels fell below this inflection point, decrease of 1 unit in serum 25-hydroxyvitamin D concentrations was linked to an 8% increase in the adjusted OR of ANA positivity (OR 0.92; 95% CI 0.87, 0.97; p 0.0026).
conclusionsIn American men, nonlinear relationships were observed between serum 25-hydroxyvitamin D concentrations and the risk of ANA positivity.
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