Evidence map›Paper›PMID 39618192›Full record

ArticleThe Veterinary record2025

Glycated haemoglobin and serum fructosamine concentrations in sick, non-diabetic dogs receiving oral prednisolone.

Ioannis L Oikonomidis, Alexandra Daravigka, Jose J Ceron, Asta Tvarijonaviciute, Froso Lambrou, Zoi Tzenetidou, Alexandros O Konstantinidis, Nectarios Soubasis

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Article in The Veterinary record, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ioannis L OikonomidisDepartment of Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Studies, University of Liverpool, Neston, UK.ORCID 0000-0002-1591-9891
Alexandra DaravigkaCompanion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Jose J CeronInterdisciplinary Laboratory of Clinical Analysis, University of Murcia, Murcia, Spain.
Asta TvarijonaviciuteInterdisciplinary Laboratory of Clinical Analysis, University of Murcia, Murcia, Spain.
Froso LambrouLabnet Laboratories, Thessaloniki, Greece.
Zoi TzenetidouCompanion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Alexandros O KonstantinidisCompanion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Nectarios SoubasisCompanion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlucocorticoids have been associated with an increased risk of developing diabetes mellitus (DM) in dogs. Glycated haemoglobin (HbA1c) and serum fructosamine have been scarcely studied in dogs receiving glucocorticoid therapy. The aim of this study was to evaluate HbA1c and fructosamine in non-diabetic dogs receiving oral prednisolone.

methodsThis was a cross-sectional study including non-diabetic dogs receiving oral prednisolone for 2 weeks or more for a diverse range of diseases. Aliquots of blood samples collected for diagnostic purposes were used. HbA1c was measured using a previously validated capillary electrophoresis assay. Fructosamine was measured using the nitroblue tetrazolium assay.

resultsForty-three adult dogs were included. The dogs received oral prednisolone (0.1‒2.3 mg/kg daily) for a median duration of 8 weeks (range: 2‒52 weeks). The median (range) glucose, fructosamine and HbA1c were 5.3 (2.6‒9.2) mmol/L, 265 (128‒388) µmol/L and 1.6% (0.8‒2.7%), respectively. Glucose increased in nine of the 43 dogs (16.2%), while fructosamine increased in eight of the 33 dogs in which it was tested (24.2%). HbA1c did not increase in any of the 40 dogs in which it was tested. LIMITATIONS: The cross-sectional study design is a limitation, as more conclusions could be drawn in a longitudinal study.

conclusionsHbA1c does not appear to be increased in sick, non-diabetic dogs receiving oral prednisolone for 2 weeks or more at the doses used in our study, whereas increases in serum fructosamine are not uncommon.

Indexed as

Dog DiseasesFructosamineGlucocorticoidsGlycated HemoglobinPrednisoloneAdministration, OralAnimalsCross-Sectional StudiesDogsFemaleMaleFructosamineGlucocorticoidsGlycated HemoglobinPrednisolonecorticosteroidsdiabetes mellitusglucocorticoidsHbA1chyperglycaemia

Identifiers

PMID39618192
PMCPMC11740410

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.