ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2024
Computed tomography versus near-infrared spectroscopy for the assessment of coronary atherosclerosis.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Plaque Progression and Rupture in Obstructive Coronary Artery Disease: A Review of Current Imaging Modalities.Reviews in cardiovascular medicine · 2026Review
- A deep learning methodology for fully-automated quantification of calcific burden in high-resolution intravascular ultrasound images.The international journal of cardiovascular imaging · 2026Article
- Advances in coronary imaging of atherosclerotic plaques.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Review
- What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
backgroundCoronary computed tomography angiography (CCTA) has been proposed as an alternative to intravascular imaging for assessing plaque pathology.
aimsWe aimed to assess the efficacy of CCTA against near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) in evaluating atheroma burden and composition and for guiding coronary interventions.
methodsSeventy patients with a chronic coronary syndrome were recruited and underwent CCTA and NIRS-IVUS. The imaging data were matched, and the estimations of lumen, vessel wall and plaque dimensions and composition of the two modalities were compared. The primary endpoint of the study was the efficacy of CCTA in detecting lipid-rich plaques identified by NIRS-IVUS. Secondary endpoints included the performance of CCTA in evaluating coronary artery pathology in the studied segments and its value in stent sizing, using NIRS-IVUS as the reference standard.
resultsIn total, 186 vessels were analysed. The attenuated plaque volume on CCTA had weak accuracy in detecting lipid-rich plaques (58%; p=0.029). Compared to NIRS-IVUS, CCTA underestimated the lumen volume (309.2 mm
conclusionsCCTA has limited efficacy in assessing plaque composition and quantifying lumen and plaque dimensions and tissue types, which may potentially impact revascularisation planning.
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Registered trials
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