Evidence map›Paper›PMID 39618886›Full record

ArticleBioactive materials2025

Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity.

Guanyu Jin, Hao Liu, Zi Mei, Qionghua Jin, Sheng Ma, Lanqing Wang, Yuanzhen Su, Letian Lv, Zijuan Wang, Huicong Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guanyu JinSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Hao LiuSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Zi MeiSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Qionghua JinDepartment of Chemistry, Capital Normal University, 100048, Beijing, PR China.
Sheng MaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022, Changchun, PR China.
Lanqing WangSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Yuanzhen SuSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Letian LvSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Zijuan WangSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Huicong ZhouSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Mingqiang LiLaboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, PR China.
Zehuan HuangSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Xuesi ChenSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.
Shixian LvSchool of Materials Science and Engineering and School of Stomatology, Peking University, 100871, Beijing, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor recurrence and metastasis after surgery are important factors affecting patient survival. The immunosuppressed tumor microenvironment after surgery reduces the ability of the immune system to clear residual tumor cells, thus increasing the risk of recurrence and metastasis. Currently, immunotherapy-based adjuvant therapy can effectively inhibit tumor recurrence and metastasis after surgery, but simultaneous and efficient synergistic activation of adaptive and innate immunity is a challenge. Here, we utilized polymeric hydrogel loaded with decitabine (DAC), cisplatin (CDDP) and manganese ions (Mn

Indexed as

Biodegradable polymersControlled drug releasePolymeric drug carriersPolymeric hydrogelsTumor recurrence and metastasis

Identifiers

PMID39618886
PMCPMC11605157

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.