ArticleInternational journal of general medicine2024
Correlation of Circulating Complement Levels with Clinical Characteristics of Patients with Diabetic Retinopathy.
Article in International journal of general medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Radical footprinting in mammalian whole blood.Nature communications · 2026Article
- The novel antidiabetic medications on diabetic retinopathy: relevant molecular mechanisms, advancing diagnostic innovations, and therapeutic implications.Frontiers in medicine · 2025Review
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Authors and funding
2 authors.
Funding
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Abstract
Background: Type 2 diabetes mellitus (T2DM) is associated with diabetic retinopathy (DR). The complement system maintains the normal physiologic microenvironment of the retina. The relationship between serum complement levels and clinical features of DR remains unclear. Methods: Clinical characteristics of 252 patients with T2DM including 101 with non-DR (NDR), 79 with nonproliferative DR (NPDR), and 72 with proliferative DR (PDR) were prospectively analyzed. Serum complement levels were compared between NDR and DR patients. The correlation between clinical characteristics and complement levels in DR patients was analyzed. A multifactorial logistic analysis was constructed to predict the risk of developing DR in T2DM. Results: Serum C4, CFB, CFI, C3 and C5 levels were higher in DR patients than in NDR patients (all Conclusion: Serum complements C3 and C5 are predictive factors for DR in patients with T2DM. The prediction model constructed by the clinical characteristics of patients with T2DM and complement can better distinguish between NDR and DR, and can be used as a potential biomarker for assessing the risk of developing DR.
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