Evidence map›Paper›PMID 39619432›Full record

Articlenpj antimicrobials and resistance2024

The putative error prone polymerase

Michelle R Agyare-Tabbi, Deeva Uthayakumar, Desiree Francis, Laetitia Maroc, Chris Grant, Peter McQueen, Garret Westmacott, Hajer Shaker, Iwona Skulska, Isabelle Gagnon-Arsenault and 3 more

Abstract read
In one paragraph

Article in npj antimicrobials and resistance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michelle R Agyare-TabbiDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Deeva UthayakumarDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Desiree FrancisDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Laetitia MarocDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Chris GrantNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3L5 Canada.
Peter McQueenNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3L5 Canada.
Garret WestmacottNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3L5 Canada.
Hajer ShakerDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Iwona SkulskaDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.
Isabelle Gagnon-ArsenaultInstitut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, QC Canada.ORCID 0000-0003-2661-1929
Jonathan BoisvertInstitut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, QC Canada.
Christian R LandryInstitut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, QC Canada.
Rebecca S ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1H 5N4 Canada.ORCID 0000-0002-7119-8865

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial-induced DNA damage, and subsequent repair via upregulation of DNA repair factors, including error-prone translesion polymerases, can lead to the increased accumulation of mutations in the microbial genome, and ultimately increased risk of acquired mutations associated with antimicrobial resistance. While this phenotype is well described in bacterial species, it is less thoroughly investigated amongst microbial fungi. Here, we monitor DNA damage induced by antifungal agents in the fungal pathogen

Indexed as

Antifungal agentsFungal genetics

Identifiers

PMID39619432
PMCPMC11606924

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.