Evidence map›Paper›PMID 39619962›Full record

ReviewFood science & nutrition2024

The effect of Myo-inositol on improving sperm quality and IVF outcomes: A systematic review and meta-analysis.

Marjan Ghaemi, Niloofar Seighali, Arman Shafiee, Maryam Beiky, Omid Kohandel Gargari, Alireza Azarboo, Vida Shafti, Kyana Jafarabady, Nasim Eshraghi, Mohammad Haddadi and 3 more

Abstract readReview
In one paragraph

Review in Food science & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Excess copper exposure and male reproductive toxicity: molecular mechanisms and potential interventions.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marjan GhaemiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-2306-7112
Niloofar SeighaliStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.
Arman ShafieeStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.ORCID https://orcid.org/0000-0002-1941-4399
Maryam BeikyStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.
Omid Kohandel GargariStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.ORCID https://orcid.org/0000-0002-8182-0582
Alireza AzarbooVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Vida ShaftiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Kyana JafarabadyStudent Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.
Nasim EshraghiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Mohammad HaddadiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Razieh AkbariVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Zahra PanahiVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Sedigheh HantoushzadehVali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-3779-9218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myo-inositol may be efficient to improve sperm parameters to increase the chance of fertility. Although, the data are controversial. This study aimed to assess the impact of Myo-inositol supplements on semen quality and in vitro fertilization (IVF) outcomes. In this systematic review and meta-analysis, a comprehensive search was conducted in PubMed, Web of Science, and Embase. The objective was to identify relevant human studies that investigated the effects of Myo-inositol treatment on various sperm factors, such as sperm motility, sperm concentration, sperm morphology, viable spermatozoa, spermatozoa with DNA fragmentation, and pregnancy rate. Additionally, the testosterone levels of patients with Oligo-astheno-teratozoospermia (OAT) after Myo-inositol application were considered. The findings of 16 selected studies from 2240 citations indicated significant improvements in several parameters of sperm after Myo-inositol administration. Myo-inositol treatment was associated with a notable increase in total sperm motility (SMD 0.90; 95% CI: 0.34 to 1.46;

Indexed as

inositolmeta‐analysisMyo‐inositololigo‐astheno‐teratozoospermiasemen analysissperm parameterssystematic review

Identifiers

PMID39619962
PMCPMC11606893

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.