Evidence map›Paper›PMID 39620369›Full record

Trial reportGut microbes

Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva.

Giovanni Musso, Mella Alberto, Filippo Mariano, Maurizio Cassader, Franco De Michieli, Antonella Riva, Giovanna Petrangolini, Stefano Togni, Silvia Pinach, Roberto Gambino

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giovanni MussoMECAU Department San Luigi Gonzaga Hospital, Turin, Italy.
Mella AlbertoDepartment of Nephrology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Filippo MarianoDepartment of Nephrology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Maurizio CassaderDepartment of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Franco De MichieliDepartment of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Antonella RivaR & D Indena S.p.A, Milan, Italy.
Giovanna PetrangoliniR & D Indena S.p.A, Milan, Italy.
Stefano TogniR & D Indena S.p.A, Milan, Italy.
Silvia PinachDepartment of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Roberto GambinoDepartment of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigate the role of homeostatic mechanisms involved in acute, postprandial nutrient metabolism and nutrient-induced systemic inflammation in CKD presence and progression in Metabolic dysfunction-associated steatohepatitis (MASH). We assessed postprandial incretins (GLP-1 and GIP), intestinotropic hormone GLP-2, endotoxin LPS, Zonulin (a marker of intestinal permeability), hepatokines, adipokines and NF-kB activation in circulating MNCs during a meal tolerance test in 52 biopsy proven MASH patients randomized to curcumin Meriva or placebo and 26 matched controls. At baseline, MASH-CKD had a lower GLP-2 response and a 2-fold higher postprandial LPS and NF-kB activation in MNCs than MASH patients without CKD, but similar remaining postprandial or fasting parameters. Postprandial IAUC GLP-2 predicted the presence of CKD in MASH (OR = 0.43, 95%CI:0.32-0.80,

Indexed as

CurcuminEndotoxemiaGlucagon-Like Peptide 2InflammationPostprandial PeriodAdultAgedFatty LiverFemaleHaptoglobinsHumansMaleMiddle AgedProtein PrecursorsCurcuminGlucagon-Like Peptide 2HaptoglobinsProtein PrecursorszonulinalbuminuriachemokineeGFRNF-kBpostprandialSteatohepatitis

Identifiers

PMID39620369
PMCPMC11633829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.