Evidence map›Paper›PMID 39620829›Full record

ArticleThe Journal of physiology2025

The background sodium leak channel NALCN is a major controlling factor in pituitary cell excitability.

Marziyeh Belal, Mariusz Mucha, Arnaud Monteil, Paul G Winyard, Robert Pawlak, Jamie J Walker, Joel Tabak, Mino D C Belle

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Getting excited about leaks: the atypical NaThe Journal of physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marziyeh BelalUniversity of Exeter Medical School, Hatherly Labs, Exeter, Devon, UK.ORCID 0000-0001-8778-0617
Mariusz MuchaUniversity of Exeter Medical School, Hatherly Labs, Exeter, Devon, UK.
Arnaud MonteilIGF, University of Montpellier, CNRS, INSERM, Montpellier, France.ORCID 0000-0003-1632-7318
Paul G WinyardUniversity of Exeter Medical School, Exeter, UK.
Robert PawlakUniversity of Exeter Medical School, Hatherly Labs, Exeter, Devon, UK.
Jamie J WalkerCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK.
Joel TabakUniversity of Exeter Medical School, Hatherly Labs, Exeter, Devon, UK.ORCID 0000-0002-0588-957X
Mino D C BelleUniversity of Exeter Medical School, Hatherly Labs, Exeter, Devon, UK.ORCID 0000-0002-4917-957X

Funding

Medical Research Council MR/N008936/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S01764X/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S01764X/2University of Exeter Medical SchoolWellcome TrustWellcome Trust ISSF WT105618MA
6 · The paper itself

Abstract

The pituitary gland produces and secretes a variety of hormones that are essential to life, such as for the regulation of growth and development, metabolism, reproduction, and the stress response. This is achieved through an intricate signalling interplay between the brain and peripheral feedback signals that shape pituitary cell excitability by regulating the ion channel properties of these cells. In addition, endocrine anterior pituitary cells spontaneously fire action potentials to regulate the intracellular calcium ([Ca

Indexed as

Ion ChannelsPituitary GlandAction PotentialsAnimalsCalciumCalcium SignalingMaleMembrane PotentialsMembrane ProteinsMiceMice, Inbred C57BLSodiumCalciumIon ChannelsMembrane ProteinsNALCN protein, mouseSodiumbackground sodium channelelectrical activityendocrine cellsNALCNnon‐selective cationic conductancepituitary cellssodium leak channels

Identifiers

PMID39620829
PMCPMC11737539

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.