Evidence map›Paper›PMID 39620933›Full record

ArticleRedox report : communications in free radical research2024

Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress.

Xiaowan Chen, Yan Ma, Ziming Yang, Dingjie Shen, Xia Li, Maowei Ni, Xiaoling Xu, Wei Chen

Abstract read
In one paragraph

Article in Redox report : communications in free radical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaowan ChenPostgraduate Training base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Yan MaDepartment of Scientific Research, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Ziming YangPostgraduate Training base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Dingjie ShenPostgraduate Training base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Xia LiPostgraduate Training base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Maowei NiZhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Xiaoling XuDepartment of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Wei ChenPostgraduate Training base Alliance of Wenzhou Medical University, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.ORCID 0000-0003-0801-5613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glutathione reductase (GR), one of the most important antioxidant enzymes in maintaining intracellular redox homeostasis, has become a novel target to suppress cancer cell growth and metastasis. In this work, we evaluated a series of naphthoquinones (NQs) as potential GR inhibitors and elucidated the mechanism of inhibition. NQ-6, one of the most potent compounds among this series, inhibited GR

Indexed as

Glutathione ReductaseNaphthoquinonesOxidative StressAnimalsEnzyme InhibitorsGlutathioneHumansMembrane Potential, MitochondrialOxidation-ReductionReactive Oxygen SpeciesEnzyme InhibitorsGlutathioneGlutathione ReductaseNaphthoquinonesReactive Oxygen SpeciesGlutathione reductase (GR)inhibitornaphthoquinoneoxidative stressS-glutathionylation

Identifiers

PMID39620933
PMCPMC11613414

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.