Evidence map›Paper›PMID 39622255›Full record

ReviewBritish journal of haematology2025

Advances and challenges in chimeric antigen receptor-natural killer cell immunotherapy for cancer.

Hind Rafei, Katayoun Rezvani

Abstract readReview
In one paragraph

Review in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Turning the tide in peritoneal metastases: Locoregional CAR-NK therapy primes systemic immunity in colorectal cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hind RafeiDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-5724-4183
Katayoun RezvaniDepartment of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REZVANI, KATY · 2003 to 2023
$43.7M
Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo, FREDERICK F LANG · 2008 to 2026
$41.2M
PR1-specific CB T cells for Patients with Myeloid MalignanciesP01CA148600 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MOLLDREM, JEFFREY J · 2011 to 2022
$24.4M
The University of Texas MD Anderson Cancer Center SPORE in Ovarian CancerP50CA281701 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ROBERT C BAST, ANIL K SOOD · 2023 to 2026
$11.5M
Off-the-shelf engineered NK cells for the treatment of AMLR01CA211044 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI REZVANI, KATY · 2017 to 2021
$2.0M
Next Generation Engineered NK Cells for Lymphoma Patients after CD19 CAR-T Cell Failure.R01CA280827 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Rafet Basar, May Daher · 2023 to 2026
$1.5M
TROP2-Directed CAR-NK Cells for the Immunotherapy of Pancreatic CancerR01CA288617 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Rafet Basar, Hind Rafei · 2024 to 2026
$1.1M
Prostate Cancer Detection Through Urine Headspace Analysis Using Colorimetric SenR43CA180466 · NCI · ISENSE MEDICAL CORPORATION · PI RHODES, PAUL · 2014 to 2014
$150k
Cancer Prevention and Research Institute of Texas RP180466Division of Cancer Prevention, National Cancer Institute 1 R01 CA211044-01Division of Cancer Prevention, National Cancer Institute 1 R01 CA288617-0Division of Cancer Prevention, National Cancer Institute 5 P01CA148600-03Division of Cancer Prevention, National Cancer Institute 5P50CA281701-02Division of Cancer Prevention, National Cancer Institute P50CA100632Division of Cancer Prevention, National Cancer Institute P50CA127001Division of Cancer Prevention, National Cancer Institute R01 CA280827-01NCI NIH HHS P01 CA148600NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA100632NCI NIH HHS P50 CA127001NCI NIH HHS P50 CA281701NCI NIH HHS R01 CA211044NCI NIH HHS R01 CA280827NCI NIH HHS R01 CA288617Stand Up To Cancer SU2C-AACR-DT-29-19The University of Texas MD Anderson Cancer Center
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR)-natural killer (NK)-cell therapy has emerged as a promising strategy in the treatment of haematological malignancies and solid cancers. Leveraging the innate immune properties of NK cells, CAR-NK-cell therapies offer potential advantages for cell therapy, including safety of use in the allogeneic setting and reduced risk of toxicity. This Nutshell provides an overview of the latest advancements in CAR-NK-cell therapy and the challenges that remain.

Indexed as

Immunotherapy, AdoptiveKiller Cells, NaturalNeoplasmsReceptors, Chimeric AntigenHumansReceptors, Chimeric AntigenCAR‐NKimmunotherapyNK cells

Identifiers

PMID39622255
PMCPMC11844749

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.