Evidence map›Paper›PMID 39622645›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Regulation of Sleep Amount by CRTC1 via Transcription of

Zhihao Liu, Zhiyong Guo, Junjie Xu, Rui Zhou, Bihan Shi, Lin Chen, Chongyang Wu, Haiyan Wang, Xia Wang, Fengchao Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhihao LiuPeking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhiyong GuoNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Junjie XuNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Rui ZhouNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Bihan ShiNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Lin ChenNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Chongyang WuNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Haiyan WangNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Xia WangNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Fengchao WangNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China.
Qi LiNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China liuqinghua@nibs.ac.cn liqi@nibs.ac.cn.
Qinghua LiuNational Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China liuqinghua@nibs.ac.cn liqi@nibs.ac.cn.ORCID 0000-0002-5996-0634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cAMP response element binding protein (CREB) is required for regulation of daily sleep amount, whereas gain of function of CREB-regulated transcription coactivator 1 (CRTC1) causes severe insomnia in mice. However, the physiological functions of CRTCs and their downstream target genes in the regulation of sleep amount remain unclear. Here, we use an adult brain chimeric (ABC)-expression/knock-out platform for somatic genetic analysis of sleep in adult male mice. ABC expression of constitutively active mutant CRTC1/2

Indexed as

Corticotropin-Releasing HormoneSleepTranscription FactorsTranscription, GeneticAnimalsBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsBdnf protein, mouseBrain-Derived Neurotrophic FactorCorticotropin-Releasing HormoneCrtc1 protein, mouseCyclic AMP Response Element-Binding ProteinTranscription Factorsadult brain chimeric (ABC)corticotropin-releasing hormone (Crh)CREBCRTCsnon-rapid eye movement sleep (NREMS)SIK3/SLP

Identifiers

PMID39622645
PMCPMC11780352

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.