Evidence map›Paper›PMID 39622811›Full record

ArticleNature communications2024

OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.

Yujie Liu, Xuechun Yang, Jian Zhou, Haijun Yang, Ruimeng Yang, Peng Zhu, Rong Zhou, Tianyuan Wu, Yongchao Gao, Zhi Ye and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Catalytic and regulatory basis of tRNA tNature communications · 2026
    Article
  4. The Effect and Molecular Mechanism ofCurrent issues in molecular biology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yujie LiuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xuechun YangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jian ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Haijun YangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ruimeng YangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Peng ZhuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Rong ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Tianyuan WuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yongchao GaoDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhi YeDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, China.
Xi LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Rong LiuDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.ORCID 0000-0003-3435-7289
Wei ZhangDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.ORCID 0000-0002-6190-3129
Honghao ZhouDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Qing LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China. liqing9251026@csu.edu.cn.ORCID 0000-0002-1787-4180

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82171467National Natural Science Foundation of China (National Science Foundation of China) 82371477National Natural Science Foundation of China (National Science Foundation of China) 82373963Natural Science Foundation of Hunan Province (Hunan Provincial Natural Science Foundation) 2024JJ5569
6 · The paper itself

Abstract

Proinsulin translation and folding is crucial for glucose homeostasis. However, islet β-cell control of Proinsulin translation remains incompletely understood. Here, we identify OSGEP, an enzyme responsible for t

Indexed as

Endoplasmic Reticulum StressGlucose IntoleranceHomeostasisInsulin-Secreting CellsProinsulinUnfolded Protein ResponseAnimalsApoptosisDiabetes Mellitus, Type 2Diet, High-FatGlucoseHumansInsulinInsulin SecretionMaleMiceGlucoseInsulinProinsulin

Identifiers

PMID39622811
PMCPMC11612026

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.