ArticleScientific reports2024
The role of nitric oxide, insulin resistance, and vitamin D in cognitive function of older adults.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Redox signaling in the heart and brain: the roles of nitric oxide and reactive oxygen species in disease and therapy.Metabolic brain disease · 2026Review
- Cognitive dysfunction in MASLD is linked to platelet activation.Frontiers in neuroscience · 2026Review
- Muscle Ultrasound Parameters and Cognitive Function in H‑type Hypertension: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Insulin Resistance and Cognitive Function in Nondiabetic Patients With Cerebral Small Vessel Disease: Role of Brain Glymphatic Function.Brain and behavior · 2025Article
- Assessment of stress hyperglycemia ratio as a prognostic indicator in geriatric intensive care patients experiencing delirium: a retrospective cohort analysis.European journal of medical research · 2025Article
- Impact of Medications for Stable Angina Pectoris on Osteoporosis: A Review of Current Evidence.Journal of multidisciplinary healthcare · 2025Review
- Declining nitric oxide bioavailability in cardiovascular aging: mechanistic insights and emerging interventions.The journal of cardiovascular aging · 2025Article
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8 authors.
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Abstract
Aging is accompanied by possible cognitive impairment, as well as a reduction in nitric oxide (NO) bioavailability, insulin resistance, and vitamin D deficiency. Among these Nitric oxide exhibits a dual role in brain biology, where both low and high levels can have detrimental effects on memory and neurotoxicity. In this study we aimed to investigate the role of nitric oxide, insulin resistance, and vitamin D in cognitive function of elderly individuals. This case-control study involved participants aged ≥ 60 years who were under observation in the Birjand Longitudinal Aging Study. A total of 40 participants were selected as controls, while 64 participants with cognitive impairment were identified as cases. The cases were further subdivided according to their Mini-Mental State Examination (MMSE) scores into two groups: mild and moderate cognitive impairment. Cognitive function in both cases and controls was assessed using the MMSE. The levels of total NOx, vitamin D, insulin, and blood glucose were measured using ELISA and spectrophotometric immunoassays. Insulin resistance indices, such as homeostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were calculated. Serum NOx levels were significantly lower in participants with cognitive impairment compared to the control group (p < 0.01). However, the mean (SD) levels of serum vitamin D, insulin, and glucose, as well as the insulin resistance markers, showed no significant differences between the groups. A positive correlation was observed between serum NOx levels and MMSE scores. NO may be an essential factor for normal brain function, as serum NOx levels were significantly higher in controls compared to those with cognitive impairment, and there was a positive correlation with MMSE scores. Other metabolic and nutritional markers, including vitamin D and insulin resistance, did not demonstrate a significant effect.
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