Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.

Zenghao Zhu, Wisam Reid, Dáibhid Ó Maoiléidigh

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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3 authors.

Zenghao ZhuDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, 94304, CA, USA.

Wisam ReidDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, 94304, CA, USA.

Dáibhid Ó MaoiléidighDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, 94304, CA, USA. dmelody@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our ears, outer-hair-cell bundles (OHBs) convert sound-induced forces into receptor currents that drive cochlear amplification, the process responsible for the micropascal-scale threshold and million-fold dynamic range of hearing. OHBs rely on gating springs to open mechanoelectrical-transduction (MET) ion channels, through which the receptor current flows. OHBs have larger gating-spring stiffnesses than other types of hair bundles, but we have a poor understanding of how gating-spring stiffness contributes to OHB mechanics and receptor-current regulation. Using experimentally-constrained mathematical models of the OHB, we show that the increased gating-spring stiffness in an OHB increases its stiffness and damping. The OHB's 3D morphology reduces the contribution of gating-spring stiffness to OHB stiffness, reduces the contribution of MET-channel gating to OHB stiffness and damping, but causes additional OHB damping that rises with gating-spring stiffness. Gating-spring stiffness increases the OHB's receptor current but decreases its displacement-current dynamic range. Strikingly, the OHB's 3D morphology causes its force-current dynamic range to decrease with gating-spring stiffness. Our results suggest a trade-off between threshold and dynamic range regulated by OHB gating-spring stiffness.

Indexed as

Hair Cells, Auditory, OuterAnimalsHearingIon Channel GatingIon ChannelsMechanotransduction, CellularModels, BiologicalIon ChannelsBalanceCell mechanicsHair bundleHair cellHearingMechanotransduction

Identifiers

PMID39622900

DOI10.1038/s41598-024-81355-5

PMCPMC11612202

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