Evidence map›Paper›PMID 39623003›Full record

ArticleScientific reports2024

Unveiling vital biomarkers and immune infiltration profiles in endoplasmic reticulum stress following spinal cord injury.

Yunpeng Zhang, Xiaoming Tang, Jian Dai, Yao Li, Jian Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunpeng Zhang *Department of Orthopedic, The Affiliated Huaian No.1 people's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China.
Xiaoming Tang *Department of Orthopedic, The Affiliated Huaian No.1 people's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China.
Jian Dai *Department of Orthopedic, The Affiliated Huaian No.1 people's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China.
Yao Li *Department of Orthopedic, The Affiliated Huaian No.1 people's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China.
Jian MaDepartment of Orthopedic, The Affiliated Huaian No.1 people's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China. orthomax838@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a profound affliction of the central nervous system that often remains inadequately addressed. Prior research has indicated that endoplasmic reticulum stress (ERS), associated with apoptotic signaling, plays a part in subsequent injuries post-SCI. However, the exact mechanisms are still unclear. ERS-related genes and SCI-associated datasets were sourced from the Genecard and GEO databases. We identified 68 ERSDEGs and pinpointed 6 marker genes vital for SCI diagnosis (CYBB, PRDX6, PTGS1, GCH1, TLR2 and PIK3CG) which were all upregulated in SCI based on bioinformatics and qRT-PCR. The nomogram exhibited that these genes could effectively predict the occurrence of SCI. Functional analysis revealed the potential roles of these genes was closely related to neuron cells and immune response. Immune infiltration research underscored the substantial roles of macrophage and CD56 dim NK cells in SCI. The ceRNA network analysis further revealed the complex interplay among marker genes, lncRNAs and miRNAs in SCI. We screened six marker genes with great diagnostic value, and found that these genes may affect the occurrence of SCI by affecting the immune response and recovery of neurons.

Indexed as

BiomarkersEndoplasmic Reticulum StressSpinal Cord InjuriesComputational BiologyGene Expression ProfilingGene Regulatory NetworksHumansMacrophagesMicroRNAsRNA, Long NoncodingBiomarkersMicroRNAsRNA, Long NoncodingEndoplasmic reticulum stressImmune landscapeMachine learningSingle-cell RNASpinal cord injury

Identifiers

PMID39623003
PMCPMC11612299

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.