ReviewAesthetic plastic surgery2025
Polylactic Acid-Based Polymers Used for Facial Rejuvenation: A Narrative Review.
Review in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study.Aesthetic surgery journal · 2026Trial
- Advances of Fully Biodegradable Poly-p-Dioxanone and Polylactic Acid-Based Polymers as Left Atrial Appendage Closure Devices.Macromolecular bioscience · 2026Review
- Needle Clogging in Biostimulator Injection: Rheological Context and Clinical Experience.Journal of cosmetic dermatology · 2026Article
- PLLA and PDLLA Fillers: Linking Crystallinity and Mechanical Stability to Aggregation, Redispersion, and Collagen Formation.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For decades, a diverse range of natural and synthetic materials have been utilized to enhance human tissue and achieve improved aesthetic results. Among these, dermal fillers are some of the most popular treatments. Initially, the primary role of dermal fillers was to restore lost volume. However, with advancements in biomaterial research, a variety of biostimulatory fillers have become essential in aesthetic medicine. One such filler, polylactic acid (PLA), has been extensively used for facial rejuvenation. Upon injection, PLA not only provides immediate volume restoration but also enhances skin quality and appearance while promoting the regeneration of collagen, elastin, and vasculature. This narrative review highlights PLA as a regenerative aesthetic treatment, detailing its physicochemical properties, mechanisms of regeneration stimulation, and clinical applications in facial aesthetics. It represents the cutting-edge foundation upon which further developments can be built to ensure optimal and safe outcomes in treatments using PLA-based collagen stimulators and other similar products for facial rejuvenation. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Indexed as
Identifiers
39623233What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.