ArticlePhysics and imaging in radiation oncology2024
Simulation-free magnetic resonance-guided radiation therapy of prostate cancer.
Article in Physics and imaging in radiation oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Direct-to-treatment MRI-guided prostate radiotherapy using a generic patient-agnostic reference plan.Technical innovations & patient support in radiation oncology · 2026Article
- Development and implementation of an MRI-only simulation, planning, and treatment workflow for prostate radiotherapy using synthetic CT on MR-linac.Journal of applied clinical medical physics · 2026Article
- Feasibility of reusing online-generated treatment plans for adaptive radiotherapy in prostate cancer.Physics and imaging in radiation oncology · 2026Article
- Simulation-free radiotherapy on the MR-linac in prostate cancer.The British journal of radiology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: Despite recent advances of online image-guided high-precision patient positioning and adaptation using magnetic resonance imaging (MRI) or cone-beam computed tomography (CT), standard radiation therapy pathway still involves a dedicated simulation scan. The aim of this study was to evaluate the feasibility and planning quality of integrating a simulation-free treatment planning workflow for adaptive online MRI-guided radiation therapy on a 1.5 T MRI linear accelerator (MRI-Linac) in prostate cancer using diagnostic CT (dCT) scans. Materials and methods: For ten patients with prostate cancer previously treated at the MRI-Linac with adaptive radiation therapy (42.7 Gy in 7 fractions), simulation-free reference plans based on dCT were retrospectively created, and adaptive plans were simulated for the first treatment fraction. Reference and adapted plans derived from both standard and simulation-free workflows were compared with regard to institutional dose/volume criteria, followed by statistical assessment using the paired Wilcoxon signed-rank test with a Bonferroni-corrected significance level of α = 0.025. Results: Simulation-free reference and adapted plans consistently met dose/volume criteria. Statistical analysis revealed no significant differences between both workflows, except median values for near-maximum dose (D2%) in the planning target volume: 44.2 Gy (standard) vs. 44.5 Gy (simulation-free) in reference plans (p = 0.01), and 44.5 Gy vs. 44.6 Gy in adapted plans (p = 0.01). Conclusion: This study demonstrated the feasibility of simulation-free radiation therapy planning using dCT. Comparable treatment plan quality was observed for both reference and adapted radiation therapy plans in a curative setting for patients with prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.