Evidence map›Paper›PMID 39624792›Full record

ArticleBiochemistry and biophysics reports2024

StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation.

Anuj Tharakan, Daniel Rodriguez-Agudo, Sheela Damle, Genta Kakiyama, William M Pandak, Gregorio Gil, Rebecca K Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anuj TharakanDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Daniel Rodriguez-AgudoDepartment of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Sheela DamleDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Genta KakiyamaDepartment of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
William M PandakDepartment of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Gregorio GilDepartment of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.
Rebecca K MartinDepartment of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA.

Funding

BLRD VA I01 BX005895
6 · The paper itself

Abstract

StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown. 25-HC has been recently described as an important suppressor of IgA + plasma cell differentiation in the Peyer's patches, and regulates the switch between germinal center and plasma cells. Since StarD5 regulates 25-HC, we examined the role of StarD5 in B cells using StarD5

Identifiers

PMID39624792
PMCPMC11609483

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.