Trial reportFrontiers in endocrinology2024
25-Hydroxyvitamin D status does not affect energy metabolism among young, healthy, non-obese adults: a metabolic chamber study.
Trial report in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Purpose: here is a general consensus that an inverse relationship exists between vitamin D status and body mass index (BMI) in overweight and obese individuals, leading to the hypothesis that vitamin D deficiency may contribute to the development of unfavorable metabolic phenotypes. However, evidence from non-obese adults remains limited. This study measured energy metabolism in non-obese adults using a metabolic chamber and explored its association with vitamin D status. Methods: Sixty-nine healthy adults (mean age = 22.8 years, mean BMI = 20.7 kg/m Results: A two-way ANOVA (seasonality × 25(OH)D) revealed no statistically significant differences in total energy expenditure, resting energy expenditure, sleeping energy expenditure, walking energy expenditure, carbohydrate oxidation rate, or fat oxidation rate among the three groups (p > 0.05). These results remained consistent even after adjusting for fat-free mass. Although statistically significant correlations were found between 25(OH)D status and certain lipid profile markers (i.e., total cholesterol, high-density lipoprotein, and free fatty acid) (p < 0.05), these correlations were weak, with Pearson's correlation coefficients below 0.3. Conclusions: Total 25(OH)D status does not affect energy metabolism in young, healthy, non-obese adults. Along with existing evidence, this suggests that low 25(OH)D status is more likely a consequence of unfavorable metabolic phenotypes rather than a contributing factor. Clinical trial registration: https://www.chictr.org.cn, identifier ChiCTR-IIR-17010604.
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