Evidence map›Paper›PMID 39624839›Full record

ArticleFrontiers in pharmacology2024

Increase in body weight is lowered when mice received fecal microbiota transfer from donor mice treated with the AT

Marco L Freschi, Axel Künstner, Gianna Huber, Ines Stölting, Hauke Busch, Misa Hirose, Walter Raasch

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marco L FreschiInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Axel KünstnerMedical Systems Biology Group, Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Gianna HuberInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Ines StöltingInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Hauke BuschMedical Systems Biology Group, Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Misa HiroseInstitute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Walter RaaschInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Treatment of rodents with the AT Methods: Seven weeks after initiating a high-fat diet (HFD), C57BL/6N mice received fecal microbiota for 8 weeks from donor mice by oral gavage, continuing HFD feeding. Stool samples came from mice that were treated with TEL (8 mg/kg/d by gavage, 12 weeks), thus remaining lean despite HFD feeding (BL/6>f Results: Weight gain was lower in BL6>f Discussion: As FMT from TEL-pretreated mice influences the microbiota in acceptor mice with slight weight-reducing effects, we confirm the relevance of TEL-related microbiota changes for weight reduction, most likely independent of the transferred stool-residual TEL effect on the host metabolism.

Indexed as

AT1 receptor antagonistdesulovibriomicrobiota transferobesityrenin-angiotensin aldosterone system (RAAS)telmisartanweight reduction

Identifiers

PMID39624839
PMCPMC11608989

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.