Evidence map›Paper›PMID 39625496›Full record

ArticleCellular and molecular life sciences : CMLS2024

Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs.

Seppe Cambier, Fabio Beretta, Amber Nooyens, Mieke Metzemaekers, Noëmie Pörtner, Janne Kaes, Ana Carolina de Carvalho, Emanuela E Cortesi, Hanne Beeckmans, Charlotte Hooft and 8 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Immature neutrophils are elevated in human PGD and linked to G-CSF-driven injury in a murine model of lung ischemia-reperfusion.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  3. Taming the Immaturity of Neutrophils Driving Injury in Lung Transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Seppe CambierLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Fabio BerettaLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Amber NooyensLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Mieke MetzemaekersLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Noëmie PörtnerLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Janne KaesLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Ana Carolina de CarvalhoLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Emanuela E CortesiLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Hanne BeeckmansLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Charlotte HooftLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Mieke GouwyLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Sofie StruyfLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium.
Rafael E MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.
Laurens J CeulemansLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Joost WautersMedical Intensive Care Unit, Department of General Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
Bart M VanaudenaerdeLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Robin VosLaboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
Paul ProostLaboratory of Molecular Immunology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega - Herestraat 49, box 1042, Leuven, 3000, Belgium. paul.proost@kuleuven.be.ORCID http://orcid.org/0000-0002-0133-5545

Funding

Fonds Wetenschappelijk Onderzoek 11A4220NFonds Wetenschappelijk Onderzoek 1803521NFonds Wetenschappelijk Onderzoek G060322NFonds Wetenschappelijk Onderzoek G0F8822NFonds Wetenschappelijk Onderzoek SB/1SHBW24NOnderzoeksraad, KU Leuven C14/23/143Onderzoeksraad, KU Leuven C16/17/010Onderzoeksraad, KU Leuven Contagious consortiumUniversitaire Ziekenhuizen Leuven, KU Leuven KOOR project
6 · The paper itself

Abstract

Elevated neutrophil counts in broncho-alveolar lavage (BAL) fluids of lung transplant (LTx) patients with chronic lung allograft dysfunction (CLAD) are associated with disease pathology. However, phenotypical characteristics of these cells remained largely unknown. Moreover, despite enhanced levels of the most potent human neutrophil-attracting chemokine CXCL8 in BAL fluid, no discrimination had been made between natural NH

Indexed as

Bronchoalveolar Lavage FluidCOVID-19Influenza, HumanInterleukin-8Lung TransplantationNeutrophilsSARS-CoV-2AdultAgedFemaleHumansLungMaleMiddle AgedNeutrophil ActivationProteolysisCXCL8 protein, humanInterleukin-8ChemokineInflammationPneumoniaProteolysisTransplant rejection

Identifiers

PMID39625496
PMCPMC11615237

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.