ArticleCell systems2024
A three-node Turing gene circuit forms periodic spatial patterns in bacteria.
Article in Cell systems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Engineered E. coli swarming for binary and analog input recording.Molecular systems biology · 2026Article
- Fundamental limits on symmetry breaking by Turing-like activator-inhibitor mechanisms.Development (Cambridge, England) · 2026Article
- How nature discovers rare Turing islands: Exploration by common limit cycles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells.bioRxiv : the preprint server for biology · 2026Article
- Revisiting Turing's Chemical Basis of Morphogenesis.Bulletin of mathematical biology · 2026Review
- Simulation of reaction-diffusion equations with reaction-reaction analog circuits.Biophysical journal · 2026Article
- Exploring the computing power of microbes that shapes the environment.Current opinion in microbiology · 2026Review
- Design of CRISPRi-Based Synthetic Gene Circuits in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2026Article
- A tool for modeling gene regulatory networks (GRN_modeler) and its applications to synthetic biology.Molecular systems biology · 2025Article
- Synthetic Forms Most Beautiful: Engineering Insights into Self-Organization.Physiology (Bethesda, Md.) · 2025Review
- Optimal network sizes for most robust Turing patterns.Scientific reports · 2025Article
- Engineering Tunable, Low Latency Spatial Computation with Dual Input Quorum Sensing Promoters.ACS synthetic biology · 2024Article
- Unraveling biochemical spatial patterns: Machine learning approaches to the inverse problem of stationary Turing patterns.iScience · 2024Article
- Engineering bacterial theranostics: from logic gates toFrontiers in bioengineering and biotechnology · 2024Review
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Turing patterns are self-organizing systems that can form spots, stripes, or labyrinths. Proposed examples in tissue organization include zebrafish pigmentation, digit spacing, and many others. The theory of Turing patterns in biology has been debated because of their stringent fine-tuning requirements, where patterns only occur within a small subset of parameters. This has complicated the engineering of synthetic Turing gene circuits from first principles, although natural genetic Turing networks have been identified. Here, we engineered a synthetic genetic reaction-diffusion system where three nodes interact according to a non-classical Turing network with improved parametric robustness. The system reproducibly generated stationary, periodic, concentric stripe patterns in growing E. coli colonies. A partial differential equation model reproduced the patterns, with a Turing parameter regime obtained by fitting to experimental data. Our synthetic Turing system can contribute to nanotechnologies, such as patterned biomaterial deposition, and provide insights into developmental patterning programs. A record of this paper's transparent peer review process is included in the supplemental information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.