Evidence map›Paper›PMID 39626674›Full record

Observational studyCell reports. Medicine2024

Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study.

Win Min Han, Hossain M S Sazzad, Mark Bloch, David A Baker, Norman Roth, Ellen Bowden-Reid, Don E Smith, Jennifer F Hoy, Ian Woolley, Robert Finlayson and 10 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04641013 (Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04641013 active not recruitingnot on this map

Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE): a follow-on Study of the Australian Positive & Peers Longevity Evaluation Study

Typeobservational_patient_registrySponsorKirby InstituteRan2017 to 2027Enrolled446ConditionsHIV Infections, Aging
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Win Min HanKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia. Electronic address: wmhan@kirby.unsw.edu.au.
Hossain M S SazzadKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia.
Mark BlochKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia; Holdsworth House Medical Practice, Sydney, NSW 2010, Australia.
David A BakerEast Sydney Doctors, Sydney, NSW 2010, Australia.
Norman RothPrahran Market Clinic, Melbourne, VIC 3181, Australia.
Ellen Bowden-ReidKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia.
Don E SmithAlbion Centre, South Eastern Sydney Local Health District, Sydney, NSW 2010, Australia; School of Population Health, University of New South Wales Sydney, Sydney, NSW 2033, Australia.
Jennifer F HoyDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, VIC 3004, Australia.
Ian WoolleyMonash Infectious Diseases, Monash Health, Clayton, VIC 3168, Australia; Centre for Inflammatory Diseases, Monash University, Clayton, VIC 3168, Australia.
Robert FinlaysonTaylor Square Private Clinic, Darlinghurst, NSW 2010, Australia.
David J TempletonDepartment of Sexual Health Medicine and Sexual Assault Medical Service, Sydney Local Health District, Sydney, NSW 2050, Australia; Discipline of Medicine, Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.
Gail V MatthewsKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia; St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
Jane CostelloPositive Life NSW, Sydney, NSW 2010, Australia.
Mark A DawsonPeter MacCallum Cancer Centre, Melbourne, VIC 3052, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3052, Australia; Centre for Cancer Research, University of Melbourne, Melbourne, VIC 3052, Australia.
Sarah-Jane DawsonPeter MacCallum Cancer Centre, Melbourne, VIC 3052, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC 3052, Australia; Centre for Cancer Research, University of Melbourne, Melbourne, VIC 3052, Australia.
Mark N PolizzottoKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia; Australian National University, Canberra, ACT 2601, Australia.
Kathy PetoumenosKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia.
Paul YehDepartment of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia; Monash Haematology, Monash Health, Clayton, VIC 3168, Australia.
Nila J DharanKirby Institute, University of New South Wales Sydney, Sydney, NSW 2033, Australia. Electronic address: ndharan@kirby.unsw.edu.au.
ARCHIVE Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

Indexed as

AgingClonal HematopoiesisHIV InfectionsAgedAged, 80 and overCohort StudiesFemaleFrailtyHumansMaleMiddle AgedMutationQuality of Lifeaging-related comorbiditiesclonal hematopoiesisfrailtygeriatric syndromesHIVmultimorbidityphenotypic age accelerationquality of life

Identifiers

PMID39626674
PMCPMC11722090

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.