Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors.
Jonathan PachecoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.ORCID 0000-0001-6880-5874
Karina A PeñaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Sofya SavranskyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Alexandre GidonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Gerald R V HammondDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.ORCID 0000-0002-6660-3272
John JanetzkoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID 0000-0003-1604-2515
Jean-Pierre VilardagaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA. jpv@pitt.edu.ORCID 0000-0002-1217-1435
Funding
Directing Membrane Function with Inositol Lipids in Health and DiseaseR35GM119412 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerald R Hammond · 2016 to 2026
$4.3M
Structure and function of PTH class B GPCRR01DK116780 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar, Jean-Pierre Vilardaga · 2018 to 2026
$4.2M
Regulation of Parathyroid Functions By G-Protein Coupled ReceptorsR01DK122259 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN, VILARDAGA, JEAN-PIERRE · 2019 to 2023
$2.2M
Predoctoral Training in Pharmacological Sciences (Resubmission)T32GM133332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tija C. Jacob, Francisco Jose Schopfer · 2020 to 2026
$1.8M
Identification of selective inhibitors of PTH-receptor for Jansen’s metaphyseal chondrodysplasiaR21DE032478 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TABOAS, JUAN MANUEL, VILARDAGA, JEAN-PIERRE · 2022 to 2023
$433k
Investigating the molecular details of assembly, disassembly and trafficking of GPCR-arrestin complexesK99GM147609 · NIGMS · STANFORD UNIVERSITY · PI JANETZKO, JOHN · 2022 to 2023
$225k
NIDCR NIH HHS R21 DE032478NIDDK NIH HHS R01 DK116780NIDDK NIH HHS R01 DK122259NIGMS NIH HHS K99 GM147609NIGMS NIH HHS R35 GM119412NIGMS NIH HHS T32 GM133332U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R21-DE032478U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01-DK116780U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) K99-GM147609U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01-DK122259U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32-GM133332
6 · The paper itself
Abstract
The assembly of a peptide ligand, its receptor, and β-arrestin (βarr) into a ternary complex within the cell membrane is a crucial aspect of G protein-coupled receptor (GPCR) signaling. We explore this assembly by attaching fluorescent moieties to the parathyroid hormone (PTH) type 1 receptor (PTH
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Fast-diffusing receptor collisions with slow-diffusing peptide ligand assemble the ternary parathyroid hormone-GPCR-arrestin complex. · full record | Socratic