Evidence map›Paper›PMID 39627481›Full record

ArticleScientific reports2024

Differentiating erythroblasts adapt to mechanical stimulation by upregulation of cholesterol biosynthesis via S1P/SREBP-induced HMGCR expression.

Giulia Iacono, Asena Abay, Joan S Gallego Murillo, Francesca Aglialoro, Nurcan Yagci, Eszter Varga, Tieme Bijlsma, Justine Sohler, Kerly Fu, Julie A Reisz and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Heterozygous nonsenseResearch and practice in thrombosis and haemostasis · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giulia Iacono *Department of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands. g.iacono@sanquin.nl.
Asena Abay *Department of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Joan S Gallego MurilloDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Francesca AglialoroDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Nurcan YagciDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Eszter VargaDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Tieme BijlsmaDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Justine SohlerDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Kerly FuDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Amy ArgabrightDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Arthur F SvendsenDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Marieke von LindernDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.
Emile van den AkkerDepartment of Hematopoiesis Sanquin Research Amsterdam and Landsteiner Laboratory, Amsterdam University Medical Center University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, The Netherlands.

Funding

The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714
6 · The paper itself

Abstract

Understanding how mechanical stress affects erythropoiesis is crucial to produce transfusable erythrocytes in fluid-turbulent bioreactors. We investigated the effects of shear-stress on differentiating CD49d

Indexed as

Cell DifferentiationCholesterolErythroblastsHydroxymethylglutaryl CoA ReductasesStress, MechanicalUp-RegulationCells, CulturedErythropoiesisHumansCholesterolHMGCR protein, humanHydroxymethylglutaryl CoA Reductases

Identifiers

PMID39627481
PMCPMC11615233

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.