ArticleNature metabolism2024
Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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Who cites it
35 citing papers in PubMed.
- Leptin-sensitive hypothalamic Lepr+/Glp1r+ neurons limit hyperphagia and weight gain in diet-induced obesity.The EMBO journal · 2026Article
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Single-cell profiling identifies obesity-disrupted brain glucose sensing.Nature communications · 2026Article
- The central amygdala gates exogenous glucagon-like peptide 1 signals.Molecular metabolism · 2026Article
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Article
- Increased leptin signaling drives the response of hypothalamic LepRb neurons to diet-induced obesity.Molecular metabolism · 2026Article
- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.Metabolism: clinical and experimental · 2026Article
- Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits.EMBO molecular medicine · 2026Review
- Molecularly defined subpopulations of leptin receptor neurons dissociate the control of food intake from blood pressure.bioRxiv : the preprint server for biology · 2026Article
- A High-Resolution Transcriptomic Atlas of Cell Types in the Ventral Visual Thalamus.Journal of neurochemistry · 2026Article
- The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition.Nature communications · 2026Article
- GLP-1 physiology and pharmacology along the gut-brain axis.The Journal of clinical investigation · 2026Review
- Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons.Obesity (Silver Spring, Md.) · 2026Article
- Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model.bioRxiv : the preprint server for biology · 2025Article
- An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding.bioRxiv : the preprint server for biology · 2025Article
- Beyond Weight Loss: GLP-1 Usage and Appetite Regulation in the Context of Eating Disorders and Psychosocial Processes.Nutrients · 2025Review
- Sensory signals for nausea.Trends in neurosciences · 2025Review
Corrections and comments
- Update of
Authors and funding
20 authors.
Addison N Webster *Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.
Jordan J Becker *Section on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Chia LiSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Dana C SchwalbeDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-1332-5184
Damien KerspernSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Eva O KarolczakSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Catherine B BundonDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0009-0007-3651-7502
Roberta A OnoharighoDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-7321-6369
Maisie CrookDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Maira JalilDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Elizabeth N GodschallDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Emily G DameSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Adam DawerSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Dylan Matthew Belmont-RauschNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6095-4891
Tune H PersNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0207-4831
Andrew LutasSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6991-2898
Naomi HabibCenter for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID http://orcid.org/0000-0002-6049-2487
Ali D GülerDepartment of Biology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-8218-850X
Michael J KrashesSection on Motivational Processes Underlying Appetite, Diabetes, Endocrinology & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. michael.krashes@nih.gov.ORCID http://orcid.org/0000-0003-0966-3401
John N CampbellNeuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA. jnc4e@virginia.edu.ORCID http://orcid.org/0000-0002-3943-8312
Funding
Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Dina Gould Halme · 1987 to 2026
$72.1MProbing neural circuits underlying satietyZIADK075087 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MInvestigating addictive/compulsive feeding behaviorZIADK075088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7MMolecular and Functional Taxonomy of Cardiovagal NeuronsR01HL153916 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAMPBELL, JOHN NELSON · 2021 to 2025
$3.1MIdentification of cell-type specific visual circuits in the ventral lateral geniculate nucleusR21EY033528 · NEI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CAMPBELL, JOHN N, FOX, MICHAEL A · 2022 to 2023
$441kAmerican Diabetes Association (ADA) 1-18-INI-14Det Frie Forskningsråd (Danish Council for Independent Research) 8045-00091BIntramural NIH HHS ZIA DK075087Intramural NIH HHS ZIA DK075088NCI NIH HHS P30 CA044579NEI NIH HHS R21 EY033528NHLBI NIH HHS R01 HL153916Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) NNF18CC0034900U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK075087U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK075088
Abstract
Liraglutide and other glucagon-like peptide 1 receptor agonists (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. One potential mechanism is by activating neurons that inhibit the hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc). To identify these afferents, we developed a method combining rabies-based connectomics with single-nucleus transcriptomics. Here, we identify at least 21 afferent subtypes of AgRP neurons in the mouse mediobasal and paraventricular hypothalamus, which are predicted by our method. Among these are thyrotropin-releasing hormone (TRH)
Indexed as
Agouti-Related ProteinGlucagon-Like Peptide 1NeuronsAnimalsArcuate Nucleus of HypothalamusConnectomeGlucagon-Like Peptide-1 ReceptorLiraglutideMaleMiceSatiationThyrotropin-Releasing HormoneAgouti-Related ProteinGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorLiraglutideThyrotropin-Releasing Hormone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.