Evidence mapPaperPMID 39629135Full record

ArticleTheranostics2024

SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis.

Qi Fang, Xiao Chen, Fei Cao, Pengfei Xu, Zheng Zhao, Roubin Lin, Di Wu, Wuguo Deng, Xuekui Liu

Abstract read
In one paragraph

Article in Theranostics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi FangDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Xiao ChenThe General Surgery Department of The Second Hospital of Anhui Medical University, Hefei, China.
Fei CaoDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Pengfei XuDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Zheng ZhaoDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Roubin LinDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Di WuDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Wuguo DengDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.
Xuekui LiuDepartment of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

B7-H1 AntigenHead and Neck NeoplasmsMatrix Metalloproteinase 1Phosphotransferases (Alcohol Group Acceptor)Squamous Cell Carcinoma of Head and NeckTumor MicroenvironmentAnimalsCell Line, TumorFemaleHumansImmune Checkpoint InhibitorsImmune EvasionImmunotherapyMaleMiceSphingosine KinaseB7-H1 AntigenCD274 protein, humanImmune Checkpoint InhibitorsMatrix Metalloproteinase 1MMP1 protein, humanPhosphotransferases (Alcohol Group Acceptor)Sphingosine KinaseSphk1 protein, mouseHNSCCMMP1PD-1.PD-L1SPHK1

Identifiers

PMID39629135
PMCPMC11610131

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.