Evidence map›Paper›PMID 39629581›Full record

ReviewCentral nervous system agents in medicinal chemistry2026

Phthalates Induced Neurotoxicity: A Mechanistic Approach.

Kajal Gaur, Yasir Hasan Siddique

Abstract readReview
PubMed Publisher
In one paragraph

Review in Central nervous system agents in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kajal GaurLaboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
Yasir Hasan SiddiqueLaboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.

Funding

University Grants Commission, New Delhi 201610028318
6 · The paper itself

Abstract

Phthalates play a significant role as plastic modifying additives in everyday items like plastics, pesticides, paints, and cosmetics. This review explores the relationship between phthalates and neurotoxicity and sheds light on the potential risks these ubiquitous chemicals pose to neurological health. The review elucidates the diverse neurotoxic effects of phthalates exposure, spanning developmental neurotoxicity, neuropathy, neurodegenerative diseases, and neurobehavioral toxicity. Mechanistic insights reveal the pathways through which phthalates induce cellular damage, including oxidative stress, disruption of calcium signalling, alteration in lipid metabolism, and interference with thyroid hormone homeostasis. Moreover, the review discusses regulatory measures aimed at restricting phthalate usage and highlights the imperative for further research and awareness to safeguard public health against the neurotoxic effects of phthalates.

Indexed as

Neurotoxicity SyndromesPhthalic AcidsAnimalsHumansOxidative Stressphthalic acidPhthalic Acidscell deathlipid metabolismmechanismneurotoxicityPhthalatesrestriction

Identifiers

PMID39629581

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.