Evidence map›Paper›PMID 39629983›Full record

ArticleApplied and environmental microbiology2025

Structural and mechanism-based engineering of sulfotransferase CHST15 for the efficient synthesis of chondroitin sulfate E.

Zhonghua Wang, Wei Song, Wanqing Wei, Hejia Qi, Weiwei Meng, Jia Liu, Xiaomin Li, Cong Gao, Liming Liu, Guipeng Hu and 2 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhonghua WangSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Wei SongSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Wanqing WeiSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.
Hejia QiSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.
Weiwei MengSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.
Jia LiuSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.
Xiaomin LiSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.ORCID 0000-0001-9205-5268
Cong GaoSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.ORCID 0000-0001-8505-2026
Liming LiuSchool of Biotechnology, Jiangnan University School of Biotechnology, Wuxi, China.
Guipeng HuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Yiwen ZhouSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.
Jing WuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi, China.ORCID 0000-0001-6911-2041

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural chondroitin sulfate (CS), extracted from animal cartilage, is widely used in the pharmaceuticals and foods. However, contamination with animal-derived heteropolysaccharides presents significant challenges, including potential immune responses. To address this, we developed a green and efficient method for synthesizing chondroitin sulfate E (CSE) via enzymatic synthesis, identifying

Indexed as

Bacterial ProteinsChondroitin SulfatesProtein EngineeringSulfotransferasesBacterial ProteinsChondroitin SulfatesSulfotransferaseschondroitin sulfate Achondroitin sulfate Eenzyme engineeringwhole‐cell catalys

Identifiers

PMID39629983
PMCPMC11784081

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.