ArticleAging cell2025
Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity.
Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The nucleus as a mechanobiological hub in muscle aging.Nucleus (Austin, Tex.) · 2026Review
- Six weeks of high-intensity interval training improve autonomic and metabolic responses in active postmenopausal women.Experimental physiology · 2026Article
- Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update.Current opinion in clinical nutrition and metabolic care · 2026Review
- Exercise-mediated regulation of mitochondrial dynamics in aging muscle: implications for mitochondrial diseases.Molecular and cellular biochemistry · 2026Review
- Alterations in submaximal cardiopulmonary indicators in CVD patients participating in APBCRE-a comprehensive CPET-based study.Frontiers in cardiovascular medicine · 2026Article
- Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025Review
- Resilience of the mitochondrial reticulum in aging.American journal of physiology. Endocrinology and metabolism · 2025Article
- Skeletal muscle mitochondrial health in type 1 diabetes: the role of exercise capacity and lifestyle factors.Diabetologia · 2025Article
- Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity.Aging cell · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Ageing substantially impairs skeletal muscle metabolic and physical function. Skeletal muscle mitochondrial health is also impaired with ageing, but the role of skeletal muscle mitochondrial fragmentation in age-related functional decline remains imprecisely characterized. Here, using a cross-sectional study design, we performed a detailed comparison of skeletal muscle mitochondrial characteristics in relation to in vivo markers of exercise capacity between young and middle-aged individuals. Despite similar overall oxidative phosphorylation capacity (young: 99 ± 17 vs. middle-aged: 99 ± 27 pmol O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.