ReviewCardiorenal medicine2025
Inflammation and Arterial Stiffness as Drivers of Cardiovascular Risk in Kidney Disease.
Review in Cardiorenal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Genetic overlap between estimated glomerular filtration rate and cardiovascular disease identifies potential targets for cardiorenal syndrome.Renal failure · 2026Article
- Biomarkers in Diabetic Kidney Disease: Early Detection, Prognostic Assessment, and Integration with Multi-Omics Signatures.Life (Basel, Switzerland) · 2026Review
- Serum Osteoprotegerin Is Associated Independently with Peripheral Arterial Stiffness in Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Carotid Atherosclerosis in Chronic Kidney Disease: Pathophysiological Mechanisms, Prevention and Tailored Clinical Management.Journal of clinical medicine · 2026Review
- Associations of nine insulin resistance-related indices with the incidence and progression of cardiovascular-liver-metabolic multimorbidity: a large prospective cohort study.Cardiovascular diabetology · 2026Article
- Article
- Gut-Derived Uremic Toxins as a Risk Factor for Vascular Damage in Patients with Chronic Kidney Disease.International journal of molecular sciences · 2026Observational
- Personalized Hemodialysis Approaches in Frail Older Individuals.Geriatrics (Basel, Switzerland) · 2026Review
- Arterial stiffness and incident chronic kidney disease risk: a two-phase retrospective cohort study.BMC nephrology · 2026Article
- Associations of eight insulin resistance-related indices and genetic risk with incident cardiometabolic multimorbidity among participants with hypertension: a large prospective cohort study.Cardiovascular diabetology · 2026Observational
- The Conventional and Alternative Therapeutic Approaches in Arterial Stiffness Management.Pharmaceutics · 2026Review
- Triglyceride-glucose-related indices and cardiovascular disease and mortality among individuals with depression: a prospective study from UK Biobank.Frontiers in nutrition · 2026Article
- Association Between Metabolic Scores for Visceral Fat and Arterial Stiffness.Vascular health and risk management · 2026Article
- Kidney transplant outcomes in obese pediatric patients.World journal of nephrology · 2025Article
- Effect of Kidney Transplant Type on Coronary Endothelial Function in Individuals with Chronic Kidney Disease.Annals of transplantation · 2025Observational
- Association Between Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Arterial Stiffness.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- SerumLife (Basel, Switzerland) · 2025Article
- Article
- Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid-Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis.Life (Basel, Switzerland) · 2025Article
- Gender Difference in Orthostatic Vascular Stiffness Increase in Young Subjects.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with chronic kidney disease (CKD) have an increased cardiovascular (CV) risk. The lower the glomerular filtration rate, the higher the CV risk. SUMMARY: Current data suggest that several uremic toxins lead to vascular inflammation and oxidative stress that, in turn, lead to endothelial dysfunction, changes in smooth muscle cells' phenotype, and increased degradation of elastin and collagen fibers. These processes lead to both functional and structural arterial stiffening and explain part of the increased risk of acute myocardial infarction and stroke reported in patients with CKD. Considering that, at least in patients with end-stage kidney disease, the reduction of arterial stiffness is associated with a parallel decrease of the CV risk; vascular function is a potential target for therapy to reduce the CV risk. KEY MESSAGES: In this review, we explore mechanisms of vascular dysfunction in CKD, paying particular attention to inflammation, reporting current data in other models of mild and severe inflammation, and discussing the vascular effect of several drugs currently used in nephrology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.