Evidence map›Paper›PMID 39631930›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2024

Digital remote maintenance inhaler adherence interventions in COPD: a systematic review and meta-analysis.

Hnin Aung, Ronnie Tan, Cara Flynn, Pip Divall, Adam Wright, Anna Murphy, Dominick Shaw, Tom J C Ward, Neil J Greening

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Observational
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. COPD and Schizophrenia.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hnin AungDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Ronnie TanDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Cara FlynnDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0009-0005-9326-966X
Pip DivallInstitute for Lung Health, NIHR Respiratory Biomedical Research Centre, University Hospitals of Leicester, Leicester, UK.
Adam WrightDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-1621-1622
Anna MurphyInstitute for Lung Health, NIHR Respiratory Biomedical Research Centre, University Hospitals of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-9046-1040
Dominick ShawDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
Tom J C WardDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-2748-4063
Neil J GreeningDepartment of Respiratory Sciences, University of Leicester, Leicester, UK neil.greening@leicester.ac.uk.ORCID https://orcid.org/0000-0003-0453-7529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSub-optimal inhaler adherence undermines the efficacy of pharmacotherapy in COPD. Digitalised care pathways are increasingly used to improve inhaler-use behaviour remotely. This review investigated the feasibility and impact of remote electronic inhaler adherence monitoring (EIM) and intervention platforms on clinical outcomes in COPD.

methodsA literature search was conducted and studies investigating maintenance inhaler use among people with COPD using digital technology were selected. Pairwise and proportional meta-analyses were employed with heterogeneity assessed using I

resultsWe included 10 studies including 1432 people with COPD whose maintenance inhaler usage was supported by digital inhalers and apps featuring audiovisual reminders and educational content with or without engagement with healthcare providers (HCPs). Inhaler adherence rate (AR) varied with calculation methods, but an overall suboptimal adherence was observed among people with COPD. HCP-led adherence interventions alongside EIM improved mean AR by 18% (95% CI 9-27)

conclusionDigitalised interventions can enhance maintenance inhaler adherence in COPD but their overall effect on clinical outcomes remains uncertain. Further work is required to tailor interventions to individuals' adherence behaviour and investigate their longer-term impact.

Indexed as

Bronchodilator AgentsMedication AdherenceNebulizers and VaporizersPulmonary Disease, Chronic ObstructiveReminder SystemsAdministration, InhalationAgedEquipment DesignFemaleHealth Knowledge, Attitudes, PracticeHumansLungMaleMiddle AgedMobile ApplicationsPatient Education as TopicBronchodilator Agents

Identifiers

PMID39631930
PMCPMC11615661

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.