ArticleNature communications2024
Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Breaking the norm: population-scale deviations of brain structure in depression and anxiety.Molecular psychiatry · 2026Article
- Associations between PTSD and psychotic symptoms: A network analysis of patients with psychotic disorders in Uganda: Psychosis-PTSD network analysis.SSM. Mental health · 2026Article
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- Symptoms of anxiety and depression in informal caregivers of persons with dementia: a latent profile analysis and computer-simulated network analysis.BMC geriatrics · 2026Article
- Association Between Clinical Symptoms and Inflammatory Markers in First-Episode Unmedicated Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2026Article
- Analysis of the trajectory of depressive symptoms and influencing factors in patients undergoing metabolic and bariatric surgery.Frontiers in endocrinology · 2026Article
- The Key Role of Somatostatin Neurons in the Suprachiasmatic Nucleus in Anxiety-Depression Comorbidity Following Sleep Deprivation.Molecular neurobiology · 2025Article
- Cognitive and neural mechanisms of mental imagery supporting creative cognition.Communications biology · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity.
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