Evidence map›Paper›PMID 39633557›Full record

ReviewHypertension (Dallas, Tex. : 1979)2025

microRNA and Hypertension.

Lishu He, Yong Liu, Michael E Widlansky, Alison J Kriegel, Qiongzi Qiu, Mingyu Liang

Abstract readReview
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lishu HeDepartment of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).ORCID 0000-0003-0730-2602
Yong LiuDepartment of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).ORCID 0000-0001-8489-1741
Michael E WidlanskyDivision of Cardiovascular Medicine, Department of Medicine (M.E.W.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0002-1461-9707
Alison J KriegelDepartment of Physiology (L.H., A.J.K.), Medical College of Wisconsin, Milwaukee.
Qiongzi QiuDepartment of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).ORCID 0000-0002-6486-6394
Mingyu LiangDepartment of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).ORCID 0000-0002-6970-989X

Funding

Sequencing Coordination and Data Analysis CoreP01HL149620 · NHLBI · UNIVERSITY OF ARIZONA · PI GEURTS, ARON M · 2020 to 2024
$11.8M
RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal DiseaseRC2DK129964 · NIDDK · UNIVERSITY OF ARIZONA · PI MINGYU LIANG · 2022 to 2026
$4.9M
Regulatory RNA in Hypertension and Renal InjuryR01HL121233 · NHLBI · UNIVERSITY OF ARIZONA · PI MINGYU LIANG · 2014 to 2026
$3.8M
Impact of L. plantarum 299v Supplementation on Endothelial Function and Systemic InflammationR01HL144098 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2019 to 2022
$2.9M
Human Coronary Artery Plaque Transcriptomes and Cardiovascular Risk AssessmentR01HL173778 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MINGYU LIANG, Michael E Widlansky · 2024 to 2026
$2.0M
Impact of L. plantarum 299v supplementation on endothelial function and inflammation in humans with type 2 diabetesK24HL152143 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2021 to 2025
$572k
NHLBI NIH HHS K24 HL152143NHLBI NIH HHS P01 HL149620NHLBI NIH HHS R01 HL121233NHLBI NIH HHS R01 HL144098NHLBI NIH HHS R01 HL173778NIDDK NIH HHS RC2 DK129964
6 · The paper itself

Abstract

Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular context-dependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modulators into the molecular system that underlies the regulation of blood pressure and the development of hypertension.

Indexed as

Blood PressureHypertensionMicroRNAsAnimalsGene Expression RegulationHumansMicroRNAsblood pressurecardiovascular systemgeneticskidneymicroRNAs

Identifiers

PMID39633557
PMCPMC11893092

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.