Evidence map›Paper›PMID 39634102›Full record

ArticleFrontiers in bioengineering and biotechnology2024

Biological and structural properties of curcumin-loaded graphene oxide incorporated collagen as composite scaffold for bone regeneration.

Qi Xie, Tianqi Wang, Lina He, Hongbo Liang, Jingxuan Sun, Xiaoxiao Huang, Weili Xie, Yumei Niu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Engineering Functional Graphenic Materials for Bone Repair.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi XieThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Tianqi WangThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Lina HeThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Hongbo LiangSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin, China.
Jingxuan SunThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Xiaoxiao HuangSchool of Materials Science and Engineering, Harbin Institute of Technology, Harbin, China.
Weili XieThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.
Yumei NiuThe First Affiliated Hospital of Harbin Medical University, School of Stomatology, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: To address the challenges related to bone defects, including osteoinductivity deficiency and post-implantation infection risk, this study developed the collagen composite scaffolds (CUR-GO-COL) with multifunctionality by integrating the curcumin-loaded graphene oxide with collagen through a freeze-drying-cross-linking process. Methods: The morphological and structural characteristics of the composite scaffolds were analyzed, along with their physicochemical properties, including water absorption capacity, water retention rate, porosity, Results: The CUR-GO-COL composite scaffold with a CUR-GO concentration of 0.05% (w/v) exhibits optimal biological compatibility and stable and slow curcumin release rate. Furthermore, Discussion: The introduction of CUR-GO into collagen scaffold creates a bone-friendly microenvironment, and offers a theoretical foundation for the design, investigation and utilization of multifunctional bone tissue biomaterials.

Indexed as

antibacterialbone regenerationcollagencurcumingraphene oxide

Identifiers

PMID39634102
PMCPMC11614606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.