Evidence map›Paper›PMID 39634108›Full record

ArticlemicroPublication biology2024

tRNA, yRNA, and rRNA fragment excisions do not involve canonical microRNA biogenesis machinery.

Noel L Godang, Anita D Nguyen, Jeffrey D DeMeis, Sunita S Paudel, Nick J Campbell, Kingston J Barnes, Kahyeon Jeon, Alayla S Roussell, Kimberly A Gregson, Glen M Borchert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noel L Godang *Pharmacology, University of South Alabama College of Medicine, Mobile, AL.
Anita D Nguyen *Pharmacology, University of South Alabama College of Medicine, Mobile, AL.
Jeffrey D DeMeisPharmacology, University of South Alabama College of Medicine, Mobile, AL.
Sunita S PaudelPharmacology, University of South Alabama College of Medicine, Mobile, AL.
Nick J CampbellComputer Science, University of South Alabama School of Computing, Mobile, AL.
Kingston J BarnesAlabama School of Mathematics and Science.
Kahyeon JeonAlabama School of Mathematics and Science.
Alayla S RoussellAlabama School of Mathematics and Science.
Kimberly A GregsonAlabama School of Mathematics and Science.
Glen M BorchertPharmacology, University of South Alabama College of Medicine, Mobile, AL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The excision of specific tRNA-derived small RNAs (tsRNAs), yRNA-derived small RNAs (ysRNAs) and ribosomal RNA-derived small RNAs (rsRNAs) is now well established. Several reports have suggested many of these fragments function much like traditional microRNAs (miRNAs). That said, whereas the expressions of the majority of appreciably expressed miRNAs in HCT116 colon cancer cells are significantly decreased in individual knockouts (KOs) of DROSHA, DGCR8, XPO5, and DICER, on average, only 3.5% of tsRNA, ysRNA, and rsRNA expressions are impaired. Conversely, tsRNA, ysRNA, and rsRNA expressions are significantly increased in each of these KOs as compared to WT. As such, although DICER has been suggested to be involved with the expression of specific tsRNAs, ysRNAs, and rsRNAs, our study finds no evidence supporting the involvement of any of these canonical miRNA biogenesis enzymes in their expressions.

Identifiers

PMID39634108
PMCPMC11615671

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.