Evidence map›Paper›PMID 39634560›Full record

ArticleiScience2024

Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation.

Toni T Lemmetyinen, Emma W Viitala, Linnea Wartiovaara, Pekka Päivinen, Heikki T Virtanen, Nalle Pentinmikko, Pekka Katajisto, Tomi P Mäkelä, Timothy C Wang, Jaan-Olle Andressoo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toni T LemmetyinenTranslational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland.
Emma W ViitalaTranslational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland.
Linnea WartiovaaraTranslational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland.
Pekka PäivinenHiLIFE-Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.
Heikki T VirtanenDepartment of Pharmacology, Faculty of Medicine, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland.
Nalle PentinmikkoThe Francis Crick Institute, London NW1 1AY, UK.
Pekka KatajistoInstitute of Biotechnology, HiLIFE, University of Helsinki, 00014 Helsinki, Finland.
Tomi P MäkeläHiLIFE-Helsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University Medical Center, New York, NY 10032, USA.
Jaan-Olle AndressooDepartment of Pharmacology, Faculty of Medicine, Helsinki Institute of Life Science, University of Helsinki, 00290 Helsinki, Finland.
Saara OllilaTranslational Cancer Medicine Program, University of Helsinki, 00014 Helsinki, Finland.

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
NCI NIH HHS R35 CA210088
6 · The paper itself

Abstract

Enteroendocrine cells (EECs) differentiate and mature to form functionally distinct populations upon migration along the intestinal crypt-villus axis, but how niche signals affect this process is poorly understood. Here, we identify expression of Glial cell line-derived neurotrophic factor (GDNF) in the intestinal subepithelial myofibroblasts (SEMFs), while the GDNF receptor RET was expressed in a subset of EECs, suggesting GDNF-mediated regulation. Indeed, GDNF-RET signaling induced increased expression of EEC genes including

Indexed as

Biological sciencesMolecular networkMolecular physiology

Identifiers

PMID39634560
PMCPMC11616604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.