Evidence map›Paper›PMID 39634878›Full record

ArticlePakistan journal of medical sciences2024

Available Oocytes rate as a predictor of clinical pregnancy outcomes in controlled ovarian stimulation: A retrospective analysis of 7933 Cycles.

Peiyang Lin, Rongshan Li, Suqin Zhu, Xiuqiong Zheng, Huiling Xu, Beihong Zheng

Abstract read
In one paragraph

Article in Pakistan journal of medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peiyang LinPeiyang Lin Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian Province, China.
Rongshan LiRongshan Li Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian Province 350001, China.
Suqin ZhuSuqin Zhu Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian Province 350001, China.
Xiuqiong ZhengXiuqiong Zheng Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian Province 350001, China.
Huiling XuHuiling Xu Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian Province 350001, China.
Beihong ZhengBeihong Zheng Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, 18 Daoshan Road, Fuzhou, Fujian Province 350001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Controlled ovarian stimulation (COS) and embryo culture may affect the development and maturation of oocytes obtained by assisted reproduction technologies (ART). This study used the concept of available oocytes rate (AOR) to evaluate the effect of COS and to identify factors that influence oocyte development and clinical pregnancy (CP). Methods: Medical data of 7933 patients who underwent oocyte retrieval and ART treatments was retrospectively reviewed at Fujian Provincial Maternity and Children's Hospital from January 2013 to December 2019. Baseline characteristics of patients, concentrations of hormones, as well as endometrial thickness, number of aspirated follicles, retrieved and available oocytes, and CP rates, were analyzed. Results: Univariate and multivariate analyses showed that basal estradiol (E2) (OR=0.98, p=0.04), endometrial thickness on human chorionic gonadotropin (hCG)-day (OR=1.25, p<0.01), number of follicles aspirated (OR=1.58, p<0.01), oocytes retrieved (OR=0.80, p=0.04), available oocytes (OR=0.48, p=0.04) and AOR (OR=1.18, p<0.01) contributed to CP. The receiver operating characteristic (ROC) curve for the CP rates showed a possible cutoff for the AOR (area under the curve (AUC)=0.788, cut off=34.13%). All 103 cycles with an AOR less than 34% were then selected as Group-A, and 103 cycles were selected as Group-C by 1:1 case-control matching. The human menopausal gonadotropin (HMG) dose was significantly different between Group-A and Group-C (1064.00±1042.01 U vs. 675.00±691.67 U, respectively, p=0.006). The duration of HMG usage was 7.88±4.73 days in Group-A and 5.79±3.59 days in Group-C (p=0.014). Conclusions: The AOR is an important indicator of oocyte function and is correlated with clinical pregnancy outcomes of fresh cycles. The AOR could objectively predict HMG as a clinically related factor that affected the number and maturation of oocytes for insemination.

Indexed as

Assisted reproductive technologyAvailable oocytes rateHuman menopausal gonadotropinOvarian responseOvulation stimulationPredictive biomarker

Identifiers

PMID39634878
PMCPMC11613380

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.