Evidence map›Paper›PMID 39634920›Full record

ArticleJournal of addiction psychiatry2024

Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders.

Gianni Martire, Daniel Sipple, David Baron, Mark S Gold, Kai-Uwe Lewandowski, Catherine A Dennen, Alireza Sharafshah, Igor Elman, Panayotis K Thanos, Edward J Modestino and 11 more

Registry-linked trialAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of addiction psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07703722 (Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07703722 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial

TypeinterventionalSponsorKhyber Medical University PeshawarRan2026 to 2027Enrolled60ConditionsMajor Depressive Disorder, Post-Traumatic Stress Disorder (PTSD)ArmsPsilocybin, Structured Integrated Reframing Therapy (SIRT), Selective Serotonin Reuptake Inhibitor (SSRI)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Gianni MartireBiophysics Research in Advanced Interdisciplinary Neuroscience at Applied Physics, New York, USA.
Daniel SippleMidwest Brain and Spine Institute, Roseville, USA.
David BaronDivision of Addiction Research, Therapy and Education, Center for Sports, Exercise and Mental Health, Western Health Sciences, Pomona, USA.
Mark S GoldDepartment of Psychiatry, Washington University School of Medicine, St. Louis, USA.
Kai-Uwe LewandowskiDivision of Personalized Pain Therapy Research & Education, Center for Advanced Spine Care of Southern Arizona, Tucson, USA.
Catherine A DennenDepartment of Family Medicine, Jefferson Health Northeast, Philadelphia, USA.
Alireza SharafshahCellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Igor ElmanCambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA.
Panayotis K ThanosDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Edward J ModestinoBrain & Behavior Laboratory, Department of Psychology, Curry College , Milton, MA., USA.
Rajendra D BadgaiyanDepartment of Psychiatry, Texas Tech University Health Sciences, School of Medicine, Lubbock, USA.
Albert PinhasovDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Abdalla BowirratDepartment of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel.
Milan MakaleDepartment of Radiation Oncology, University of California San Diego, La Jolla, CA, USA.
A Kenison RoyDepartment of Psychiatry, Tulane University School of Medicine, New Orleans, LA., USA.
Keerthy SunderKarma Doctors & Karma TMS, and Suder Foundation, Palm Springs, CA, USA.
Kevin T MurphyDivision of personalized neuromodulation, Peak Logic, LLC., Del Mar, CA., USA.
Shaurya MahajanKarma Doctors & Karma TMS, and Suder Foundation, Palm Springs, CA, USA.
Yatharth MahajanKarma Doctors & Karma TMS, and Suder Foundation, Palm Springs, CA, USA.
Chynna LevinThe Blum Neurogenetic & Behavioral Institute, LLC., Austin, USA.
Kenenth BlumDivision of Addiction Research, Therapy and Education, Center for Sports, Exercise and Mental Health, Western Health Sciences, Pomona, USA.

Funding

Dopamine Neurotransmission in Tourette SyndromeR01NS073884 · NINDS · UNIVERSITY OF MINNESOTA · PI BADGAIYAN, RAJENDRA D · 2012 to 2016
$2.2M
A Systematic Medical Approach to Reward Transformation (SMART) for Brain Health in Opioid Use DisorderR41MD012318 · NIMHD · VERSA INTEGRATED SOLUTIONS, INC. · PI BLUM, KENNETH, GONDRE-LEWIS, MARJORIE C · 2017 to 2017
$221k
NIMHD NIH HHS R41 MD012318NINDS NIH HHS R01 NS073884
6 · The paper itself

Abstract

Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) share overlapping neurobiological mechanisms particularly reward deficiency and stress-like anti-reward processes. And so, BPD may be reclassified as a "traumatic personality stress disorder" (TPSD) with ensuing common therapeutic strategies that may stabilize dopaminergic reward function such as psychedelic-assisted therapy. Integrated therapeutic strategies may be further supported by genetic studies aimed at assessing similarities between the two therapeutic entities. In this perspective we theorize that psychedelic assisted therapy (PAT) may play a role in the treatment of trauma induced personality disorders. This study identifies PAT as a pathway for treating both BPD and PTSD, proposing that reframing BPD as TPSD could lead to more effective, personalized interventions, ultimately improving the quality of life for those affected by trauma. Such a reclassification might also mitigate stigma, enhance our understanding of the underlying mechanisms, and optimize therapeutic interventions for a broader range of diagnostic categories characterized by anhedonia, negative affective states, hypervigilance, and dissociation.

Indexed as

Borderline personality disorderPost-traumatic stress disorderPsilocybinPsychedelic assisted therapyTrauma

Identifiers

PMID39634920
PMCPMC11616086

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.