Evidence map›Paper›PMID 39635846›Full record

ArticleInternational journal of molecular medicine2025

Artesunate protects against a mouse model of cerulein and lipopolysaccharide‑induced acute pancreatitis by inhibiting TLR4‑dependent autophagy.

Dan Liu, Chao Liu, Fei Deng, Fumin Ouyang, Rongxin Qin, Zhaoxia Zhai, Yan Wang, Yu Zhang, Mengling Liao, Xichun Pan and 4 more

Abstract read
In one paragraph

Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dan Liu *Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Chao Liu *Department of Pharmaceutical Chemistry, College of Pharmacy, Army Medical University (The Third Military Medical University), Chongqing 400016, P.R. China.
Fei Deng *Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Fumin OuyangKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Rongxin QinDepartment of Pharmaceutical Chemistry, College of Pharmacy, Army Medical University (The Third Military Medical University), Chongqing 400016, P.R. China.
Zhaoxia ZhaiKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Yan WangKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Yu ZhangKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Mengling LiaoKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Xichun PanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Army Medical University (The Third Military Medical University), Chongqing 400016, P.R. China.
Yasi HuangKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Yanyan CenDepartment of Pharmaceutical Chemistry, College of Pharmacy, Army Medical University (The Third Military Medical University), Chongqing 400016, P.R. China.
Xiaoli LiDepartment of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P.R. China.
Hong ZhouKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute pancreatitis (SAP) is a severe clinical condition associated with high rates of morbidity and mortality. Multiple organ dysfunction syndrome that follows systemic inflammatory response syndrome is the leading cause of SAP‑related death. Since the inflammatory mechanism of SAP remains unclear, there is currently a lack of effective drugs available for its treatment. Therefore, it is important to study effective therapeutic drugs and their molecular mechanisms based on studying the inflammatory mechanism of SAP. In the present study,

Indexed as

ArtesunateAutophagyCeruletideDisease Models, AnimalLipopolysaccharidesPancreatitisToll-Like Receptor 4AnimalsCytokinesMaleMicePancreasProtective AgentsRAW 264.7 CellsSignal TransductionArtesunateCeruletideCytokinesLipopolysaccharidesProtective AgentsTlr4 protein, mouseToll-Like Receptor 4acute pancreatitisartesunateautophagyceruleinlipopolysaccharidetrypsin

Identifiers

PMID39635846
PMCPMC11637502

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.