Evidence map›Paper›PMID 39636057›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2025

Effect of Common Medications on Longitudinal Pectoralis Muscle Area in Smokers.

Toru Shirahata, Nicholas A Enzer, Victor Castro, Joe Chiles, Merry-Lynn McDonald, Bina Choi, Alejandro A Diaz, George R Washko, Raúl San José Estépar, Samuel Y Ash and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00608764 active not recruitingnot on this map

Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2028Enrolled10,718ConditionsPulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toru ShirahataApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Nicholas A EnzerApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Victor CastroBoston University School of Medicine, Boston, Massachusetts, United States.
Joe ChilesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States.
Merry-Lynn McDonaldDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States.
Bina ChoiApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Alejandro A DiazApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
George R WashkoApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Raúl San José EstéparApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Samuel Y AshDepartment of Critical Care Medicine, South Shore Hospital, South Weymouth, Massachusetts, United States.
Farbod N RahaghiApplied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
COPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics ApproachesR01HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2021 to 2024
$2.7M
AstraZenecaBayer PharmaceuticalsBoehringer-IngelheimGenentechGlaxoSmithKlineNHLBI NIH HHS R01 HL153460NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NovartisPfizerSunovion
6 · The paper itself

Abstract

Background: Cigarette smoke contributes to skeletal muscle wasting. While exercise and nutritional therapies are effective in improving skeletal muscle quantity and quality, the effect of medications on longitudinal muscle loss is unclear. We investigated whether long-term use of common medications affects longitudinal skeletal muscle changes in current and former smokers. Methods: Using quantitative computed tomography imaging, we measured the 5-year changes in pectoralis muscle area (delta-PMA) and pectoralis muscle density (delta-PMD) of 4191 participants in the COPD Genetic Epidemiology (COPDGene Results: Over the study period, the median delta-PMA for the entire population showed a decrease of 2.23cm Conclusion: In current and former smokers, statin use was associated with reduced pectoralis muscle wasting, while aspirin use was associated with increased muscle loss. Additional research is needed to verify these findings. (Clinicaltrials.gov identifier NCT00608764).

Indexed as

aspirinpectoralis muscle deteriorationsmokerstatin

Identifiers

PMID39636057
PMCPMC11925068

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.